Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task
Episodic memory depends on the recollection of spatial and temporal aspects of past experiences in which the hippocampus plays a critical role. Studies on hippocampal lesions in rodents have shown that dentate gyrus (DG) and CA3 are necessary to detect object displacement in memory tasks. However, t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.970083/full |
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| author | Lívia Neves Bruno Lobão-Soares Bruno Lobão-Soares Ana Paula de Castro Araujo Ana Paula de Castro Araujo Alan Michel Bezerra Furtunato Izabela Paiva Nicholy Souza Anne Kelly Morais George Nascimento Elaine Gavioli Elaine Gavioli Adriano Bretanha Lopes Tort Flávio Freitas Barbosa Flávio Freitas Barbosa Hindiael Belchior Hindiael Belchior |
| author_facet | Lívia Neves Bruno Lobão-Soares Bruno Lobão-Soares Ana Paula de Castro Araujo Ana Paula de Castro Araujo Alan Michel Bezerra Furtunato Izabela Paiva Nicholy Souza Anne Kelly Morais George Nascimento Elaine Gavioli Elaine Gavioli Adriano Bretanha Lopes Tort Flávio Freitas Barbosa Flávio Freitas Barbosa Hindiael Belchior Hindiael Belchior |
| author_sort | Lívia Neves |
| collection | DOAJ |
| description | Episodic memory depends on the recollection of spatial and temporal aspects of past experiences in which the hippocampus plays a critical role. Studies on hippocampal lesions in rodents have shown that dentate gyrus (DG) and CA3 are necessary to detect object displacement in memory tasks. However, the understanding of real-time oscillatory activity underlying memory discrimination of subtle and pronounced displacements remains elusive. Here, we chronically implanted microelectrode arrays in adult male Wistar rats to record network oscillations from DG, CA3, and CA1 of the dorsal hippocampus while animals executed an object recognition task of high and low spatial displacement tests (HD: 108 cm, and LD: 54 cm, respectively). Behavioral analysis showed that the animals discriminate between stationary and displaced objects in the HD but not LD conditions. To investigate the hypothesis that theta and gamma oscillations in different areas of the hippocampus support discrimination processes in a recognition memory task, we compared epochs of object exploration between HD and LD conditions as well as displaced and stationary objects. We observed that object exploration epochs were accompanied by strong rhythmic activity in the theta frequency (6–12 Hz) band in the three hippocampal areas. Comparison between test conditions revealed higher theta band power and higher theta-gamma phase-amplitude coupling in the DG during HD than LD conditions. Similarly, direct comparison between displaced and stationary objects within the HD test showed higher theta band power in CA3 during exploration of displaced objects. Moreover, the discrimination index between displaced and stationary objects directly correlated with CA1 gamma band power in epochs of object exploration. We thus conclude that theta and gamma oscillations in the dorsal hippocampus support the successful discrimination of object displacement in a recognition memory task. |
| first_indexed | 2024-04-12T00:48:28Z |
| format | Article |
| id | doaj.art-a849d1961d9e4a5c8c12f68eb8ddc5b0 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-12T00:48:28Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-a849d1961d9e4a5c8c12f68eb8ddc5b02022-12-22T03:54:48ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-12-011610.3389/fnbeh.2022.970083970083Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory taskLívia Neves0Bruno Lobão-Soares1Bruno Lobão-Soares2Ana Paula de Castro Araujo3Ana Paula de Castro Araujo4Alan Michel Bezerra Furtunato5Izabela Paiva6Nicholy Souza7Anne Kelly Morais8George Nascimento9Elaine Gavioli10Elaine Gavioli11Adriano Bretanha Lopes Tort12Flávio Freitas Barbosa13Flávio Freitas Barbosa14Hindiael Belchior15Hindiael Belchior16Graduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, RN, BrazilGraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, RN, BrazilDepartment of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, BrazilGraduate Program in Cognitive Neuroscience and Behavior, Federal University of Paraíba, João Pessoa, PB, BrazilDepartment of Psychology, Federal University of Paraíba, João Pessoa, PB, BrazilGraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, RN, BrazilBrain Institute, Federal University of Rio Grande do Norte, Natal, RN, BrazilGraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, RN, BrazilGraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, RN, BrazilDepartment of Biomedical Engineering, Federal University of Rio Grande do Norte, Natal, RN, BrazilGraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, RN, BrazilDepartment of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, BrazilBrain Institute, Federal University of Rio Grande do Norte, Natal, RN, BrazilGraduate Program in Cognitive Neuroscience and Behavior, Federal University of Paraíba, João Pessoa, PB, BrazilDepartment of Psychology, Federal University of Paraíba, João Pessoa, PB, BrazilGraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, RN, BrazilDepartment of Physical Education, Federal University of Rio Grande do Norte, Natal, RN, BrazilEpisodic memory depends on the recollection of spatial and temporal aspects of past experiences in which the hippocampus plays a critical role. Studies on hippocampal lesions in rodents have shown that dentate gyrus (DG) and CA3 are necessary to detect object displacement in memory tasks. However, the understanding of real-time oscillatory activity underlying memory discrimination of subtle and pronounced displacements remains elusive. Here, we chronically implanted microelectrode arrays in adult male Wistar rats to record network oscillations from DG, CA3, and CA1 of the dorsal hippocampus while animals executed an object recognition task of high and low spatial displacement tests (HD: 108 cm, and LD: 54 cm, respectively). Behavioral analysis showed that the animals discriminate between stationary and displaced objects in the HD but not LD conditions. To investigate the hypothesis that theta and gamma oscillations in different areas of the hippocampus support discrimination processes in a recognition memory task, we compared epochs of object exploration between HD and LD conditions as well as displaced and stationary objects. We observed that object exploration epochs were accompanied by strong rhythmic activity in the theta frequency (6–12 Hz) band in the three hippocampal areas. Comparison between test conditions revealed higher theta band power and higher theta-gamma phase-amplitude coupling in the DG during HD than LD conditions. Similarly, direct comparison between displaced and stationary objects within the HD test showed higher theta band power in CA3 during exploration of displaced objects. Moreover, the discrimination index between displaced and stationary objects directly correlated with CA1 gamma band power in epochs of object exploration. We thus conclude that theta and gamma oscillations in the dorsal hippocampus support the successful discrimination of object displacement in a recognition memory task.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.970083/fullhippocampuslocal field potentialsrecognition memoryspatial displacement of objectspattern separation |
| spellingShingle | Lívia Neves Bruno Lobão-Soares Bruno Lobão-Soares Ana Paula de Castro Araujo Ana Paula de Castro Araujo Alan Michel Bezerra Furtunato Izabela Paiva Nicholy Souza Anne Kelly Morais George Nascimento Elaine Gavioli Elaine Gavioli Adriano Bretanha Lopes Tort Flávio Freitas Barbosa Flávio Freitas Barbosa Hindiael Belchior Hindiael Belchior Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task Frontiers in Behavioral Neuroscience hippocampus local field potentials recognition memory spatial displacement of objects pattern separation |
| title | Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task |
| title_full | Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task |
| title_fullStr | Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task |
| title_full_unstemmed | Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task |
| title_short | Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task |
| title_sort | theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task |
| topic | hippocampus local field potentials recognition memory spatial displacement of objects pattern separation |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.970083/full |
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