Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study
Objective: To determine the prevalence of drug-related problems and the factors influencing them among adult psychiatric inpatients. Methods: A multi-centre cross-sectional observational study was conducted from April to July 2021 at five randomly selected hospitals in Northwest Ethiopia. A total of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-08-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121221112485 |
| _version_ | 1798037135210577920 |
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| author | Ephrem Mebratu Dagnew Mohammed Biset Ayalew Gizework Alemnew Mekonnen Alehegn Bishaw Geremew Ousman Abubeker Abdela |
| author_facet | Ephrem Mebratu Dagnew Mohammed Biset Ayalew Gizework Alemnew Mekonnen Alehegn Bishaw Geremew Ousman Abubeker Abdela |
| author_sort | Ephrem Mebratu Dagnew |
| collection | DOAJ |
| description | Objective: To determine the prevalence of drug-related problems and the factors influencing them among adult psychiatric inpatients. Methods: A multi-centre cross-sectional observational study was conducted from April to July 2021 at five randomly selected hospitals in Northwest Ethiopia. A total of 325 consecutively sampled patients participated in the study. Clinical pharmacists assessed the drug-related problems based on clinical judgement supported by updated evidence-based disease guidelines. We used the Medscape drug-interactions checker to check drug-to-drug interactions. The results were summarised using descriptive statistics, including frequency, mean, and standard deviation. For each variable, an odds ratio with a 95% confidence interval was calculated, as well as the related p -value. The value of p ⩽ 0.05 was considered statistically significant. Results: From the total number of 325 study participants, more than half of them (52.9%) were females, and the mean age ± (standard deviation) was 30.8 ± 11.3 years. At least one drug-related problem was recorded by 60.9% to 95% confidence interval (55.7–65.8) of study participants, with a mean of 0.6 ± 0.49 per patient. Additional drug therapy was the most common drug-related problem (22.8%) followed by non-adherence to medicine (20.6%) and adverse drug reactions (11%), respectively. Factors independent associated with drug-related problems were rural residence (adjusted odds ratio = 1.96, 95% confidence interval: 1.01–2.84, p -value = 0.046), self-employed (adjusted odds ratio = 6.0, 95% confidence interval: 1.0–36.9, p -value = 0.035) and alcohol drinkers (adjusted odds ratio = 6.40, 95% confidence interval: 1.12–37.5, p -value = 0.034). Conclusion: The prevalence of drug-related problems among adult psychiatric patients admitted to psychiatric wards was high. Healthcare providers give more attention to tackling these problems. Being a rural resident, self-employed, and alcohol drinkers were associated with drug-related problems. |
| first_indexed | 2024-04-11T21:22:28Z |
| format | Article |
| id | doaj.art-a849d2845e884139836635617fd5a8bd |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-04-11T21:22:28Z |
| publishDate | 2022-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-a849d2845e884139836635617fd5a8bd2022-12-22T04:02:34ZengSAGE PublishingSAGE Open Medicine2050-31212022-08-011010.1177/20503121221112485Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional studyEphrem Mebratu Dagnew0Mohammed Biset Ayalew1Gizework Alemnew Mekonnen2Alehegn Bishaw Geremew3Ousman Abubeker Abdela4Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaPharmacy, School of Rural Medicine, University of New England, Armidale, NSW, AustraliaDepartment of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Reproductive Health, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaObjective: To determine the prevalence of drug-related problems and the factors influencing them among adult psychiatric inpatients. Methods: A multi-centre cross-sectional observational study was conducted from April to July 2021 at five randomly selected hospitals in Northwest Ethiopia. A total of 325 consecutively sampled patients participated in the study. Clinical pharmacists assessed the drug-related problems based on clinical judgement supported by updated evidence-based disease guidelines. We used the Medscape drug-interactions checker to check drug-to-drug interactions. The results were summarised using descriptive statistics, including frequency, mean, and standard deviation. For each variable, an odds ratio with a 95% confidence interval was calculated, as well as the related p -value. The value of p ⩽ 0.05 was considered statistically significant. Results: From the total number of 325 study participants, more than half of them (52.9%) were females, and the mean age ± (standard deviation) was 30.8 ± 11.3 years. At least one drug-related problem was recorded by 60.9% to 95% confidence interval (55.7–65.8) of study participants, with a mean of 0.6 ± 0.49 per patient. Additional drug therapy was the most common drug-related problem (22.8%) followed by non-adherence to medicine (20.6%) and adverse drug reactions (11%), respectively. Factors independent associated with drug-related problems were rural residence (adjusted odds ratio = 1.96, 95% confidence interval: 1.01–2.84, p -value = 0.046), self-employed (adjusted odds ratio = 6.0, 95% confidence interval: 1.0–36.9, p -value = 0.035) and alcohol drinkers (adjusted odds ratio = 6.40, 95% confidence interval: 1.12–37.5, p -value = 0.034). Conclusion: The prevalence of drug-related problems among adult psychiatric patients admitted to psychiatric wards was high. Healthcare providers give more attention to tackling these problems. Being a rural resident, self-employed, and alcohol drinkers were associated with drug-related problems.https://doi.org/10.1177/20503121221112485 |
| spellingShingle | Ephrem Mebratu Dagnew Mohammed Biset Ayalew Gizework Alemnew Mekonnen Alehegn Bishaw Geremew Ousman Abubeker Abdela Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study SAGE Open Medicine |
| title | Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study |
| title_full | Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study |
| title_fullStr | Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study |
| title_full_unstemmed | Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study |
| title_short | Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study |
| title_sort | drug related problems and associated factors among adult psychiatric inpatients in northwest ethiopia multicenter cross sectional study |
| url | https://doi.org/10.1177/20503121221112485 |
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