Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review
Obesity has become an emerging health issue worldwide that continues to grow in females of reproductive age as well. Obesity, as a multisystem and chronic disease, is associated with metabolic inflammation, which is defined as chronic low-grade systemic inflammation mediated by, i.a., adipose tissue...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/11/565 |
| _version_ | 1797459685874335744 |
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| author | Dominika Mazur Małgorzata Satora Anna K. Rekowska Zuzanna Kabała Aleksandra Łomża Żaneta Kimber-Trojnar Bożena Leszczyńska-Gorzelak |
| author_facet | Dominika Mazur Małgorzata Satora Anna K. Rekowska Zuzanna Kabała Aleksandra Łomża Żaneta Kimber-Trojnar Bożena Leszczyńska-Gorzelak |
| author_sort | Dominika Mazur |
| collection | DOAJ |
| description | Obesity has become an emerging health issue worldwide that continues to grow in females of reproductive age as well. Obesity, as a multisystem and chronic disease, is associated with metabolic inflammation, which is defined as chronic low-grade systemic inflammation mediated by, i.a., adipose tissue macrophages. Lactation has been proven to have a beneficial influence on maternal health and could help restore metabolic balance, especially in the state of maternal obesity. In this review, we aimed to analyze the influence of breastfeeding on chronic low-grade meta-inflammation caused by obesity. We performed a comprehensive literature review using the PubMed, Science Direct, and Google Scholar electronic databases. For this purpose, we searched for “metabolic inflammation”; “meta-inflammation”; “obesity”; “breastfeeding”; “fetal programming”; “energy metabolism”; “postpartum”; “immunity”; “immune system”; and “inflammation” keyword combinations. While the clinical impact of breastfeeding on maternal and offspring health is currently well known, we decided to gain insight into more specific metabolic effects of adiposity, lipid, and glucose homeostasis, and immunological effects caused by the activity of cytokines, macrophages, and other immune system cells. Further research on the immunological and metabolic effects of breastfeeding in obese patients is key to understanding and potentially developing obesity therapeutic strategies. |
| first_indexed | 2024-03-09T16:55:59Z |
| format | Article |
| id | doaj.art-a84ab41ccf794ed0914e4cc35fb8c4fe |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T16:55:59Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-a84ab41ccf794ed0914e4cc35fb8c4fe2023-11-24T14:36:09ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-11-0145119003901810.3390/cimb45110565Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative ReviewDominika Mazur0Małgorzata Satora1Anna K. Rekowska2Zuzanna Kabała3Aleksandra Łomża4Żaneta Kimber-Trojnar5Bożena Leszczyńska-Gorzelak6Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-059 Lublin, PolandObesity has become an emerging health issue worldwide that continues to grow in females of reproductive age as well. Obesity, as a multisystem and chronic disease, is associated with metabolic inflammation, which is defined as chronic low-grade systemic inflammation mediated by, i.a., adipose tissue macrophages. Lactation has been proven to have a beneficial influence on maternal health and could help restore metabolic balance, especially in the state of maternal obesity. In this review, we aimed to analyze the influence of breastfeeding on chronic low-grade meta-inflammation caused by obesity. We performed a comprehensive literature review using the PubMed, Science Direct, and Google Scholar electronic databases. For this purpose, we searched for “metabolic inflammation”; “meta-inflammation”; “obesity”; “breastfeeding”; “fetal programming”; “energy metabolism”; “postpartum”; “immunity”; “immune system”; and “inflammation” keyword combinations. While the clinical impact of breastfeeding on maternal and offspring health is currently well known, we decided to gain insight into more specific metabolic effects of adiposity, lipid, and glucose homeostasis, and immunological effects caused by the activity of cytokines, macrophages, and other immune system cells. Further research on the immunological and metabolic effects of breastfeeding in obese patients is key to understanding and potentially developing obesity therapeutic strategies.https://www.mdpi.com/1467-3045/45/11/565breastfeedingobesitymetabolic inflammationmetabolic programmingenergy metabolismimmunology |
| spellingShingle | Dominika Mazur Małgorzata Satora Anna K. Rekowska Zuzanna Kabała Aleksandra Łomża Żaneta Kimber-Trojnar Bożena Leszczyńska-Gorzelak Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review Current Issues in Molecular Biology breastfeeding obesity metabolic inflammation metabolic programming energy metabolism immunology |
| title | Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review |
| title_full | Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review |
| title_fullStr | Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review |
| title_full_unstemmed | Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review |
| title_short | Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review |
| title_sort | influence of breastfeeding on the state of meta inflammation in obesity a narrative review |
| topic | breastfeeding obesity metabolic inflammation metabolic programming energy metabolism immunology |
| url | https://www.mdpi.com/1467-3045/45/11/565 |
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