Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

Abstract The bony skeleton is continuously renewed throughout adult life by the bone remodeling process, in which old or damaged bone is removed by osteoclasts via largely unknown mechanisms. Osteocytes regulate bone remodeling by producing the osteoclast differentiation factor RANKL (encoded by the...

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Bibliographic Details
Main Authors: Minglu Yan, Masayuki Tsukasaki, Ryunosuke Muro, Yutaro Ando, Kazutaka Nakamura, Noriko Komatsu, Takeshi Nitta, Tadashi Okamura, Kazuo Okamoto, Hiroshi Takayanagi
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-023-00277-6

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https://doi.org/10.1038/s41413-023-00277-6

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