Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccination
Objectives: To describe the current panorama of severe chickenpox disease and seroprevalence in Sweden, as a basis for the approaching decision on universal vaccination.Methods: Patients discharged with an International Classificationof Diseases 10th revision-code for chickenpox (B01-B01.9) in eight...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221006445 |
| _version_ | 1818717375170609152 |
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| author | K Widgren L Persson Berg A Mörner L Lindquist A Tegnell J Giesecke M Studahl |
| author_facet | K Widgren L Persson Berg A Mörner L Lindquist A Tegnell J Giesecke M Studahl |
| author_sort | K Widgren |
| collection | DOAJ |
| description | Objectives: To describe the current panorama of severe chickenpox disease and seroprevalence in Sweden, as a basis for the approaching decision on universal vaccination.Methods: Patients discharged with an International Classificationof Diseases 10th revision-code for chickenpox (B01-B01.9) in eight pediatric and infectious diseases departments in Stockholm and Gothenburg in 2012-2014 were included in the study and their medical charts were reviewed. Further, residual serum samples collected from 11 laboratories across Sweden were analyzed for varicella zoster IgG-antibodies to investigate age-specific seroprevalence.Results: A total of 218 children and 46 adults were included in this hospital-based study; 87.2% of children and 63.0% of adults had complications. An underlying condition was not associated with an increased risk of complication. Dehydration (31.7%), bacterial skin infections (29.8%) and neurological involvement (20.6%) were the most frequent complications in children. Among adult cases, 63% were born abroad. The seroepidemiological analysis included 957 patient samples. Seroprevalence was 66.7% at 5 years and 91.5% at 12 years. Infants and adolescents/adults were overrepresented among admitted patients compared to seroprevalence data.Conclusions: Half of all complications in hospitalized chickenpox cases were seen in previously healthy children, which supports universal childhood vaccination. Adult migrants was a risk group for chickenpox hospitalization. Age-specific seroprevalence was similar to neighboring countries. |
| first_indexed | 2024-12-17T19:34:09Z |
| format | Article |
| id | doaj.art-a84d7872c58240f584e3fa7643206326 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-17T19:34:09Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-a84d7872c58240f584e3fa76432063262022-12-21T21:35:11ZengElsevierInternational Journal of Infectious Diseases1201-97122021-10-011119298Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccinationK Widgren0L Persson Berg1A Mörner2L Lindquist3A Tegnell4J Giesecke5M Studahl6Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden; Department of Public Health Analysis and Data Management, the Public Health Agency of Sweden, Solna, Sweden; Corresponding author: Department of Medicine, Huddinge, C2:94, Karolinska University Hospital Huddinge, 141 86 Stockholm, SwedenDepartment of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Microbiology, the Public Health Agency of Sweden, Solna, SwedenDepartment of Medicine, Huddinge, Karolinska Institute, Stockholm, SwedenDepartment of Public Health Analysis and Data Management, the Public Health Agency of Sweden, Solna, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, SwedenDepartment of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden; Department of Infectious Diseases, Sahlgrenska University Hospital, Gothenburg, SwedenObjectives: To describe the current panorama of severe chickenpox disease and seroprevalence in Sweden, as a basis for the approaching decision on universal vaccination.Methods: Patients discharged with an International Classificationof Diseases 10th revision-code for chickenpox (B01-B01.9) in eight pediatric and infectious diseases departments in Stockholm and Gothenburg in 2012-2014 were included in the study and their medical charts were reviewed. Further, residual serum samples collected from 11 laboratories across Sweden were analyzed for varicella zoster IgG-antibodies to investigate age-specific seroprevalence.Results: A total of 218 children and 46 adults were included in this hospital-based study; 87.2% of children and 63.0% of adults had complications. An underlying condition was not associated with an increased risk of complication. Dehydration (31.7%), bacterial skin infections (29.8%) and neurological involvement (20.6%) were the most frequent complications in children. Among adult cases, 63% were born abroad. The seroepidemiological analysis included 957 patient samples. Seroprevalence was 66.7% at 5 years and 91.5% at 12 years. Infants and adolescents/adults were overrepresented among admitted patients compared to seroprevalence data.Conclusions: Half of all complications in hospitalized chickenpox cases were seen in previously healthy children, which supports universal childhood vaccination. Adult migrants was a risk group for chickenpox hospitalization. Age-specific seroprevalence was similar to neighboring countries.http://www.sciencedirect.com/science/article/pii/S1201971221006445ChickenpoxHospitalizationSeroepidemiologic studiesSeroprevalence |
| spellingShingle | K Widgren L Persson Berg A Mörner L Lindquist A Tegnell J Giesecke M Studahl Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccination International Journal of Infectious Diseases Chickenpox Hospitalization Seroepidemiologic studies Seroprevalence |
| title | Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccination |
| title_full | Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccination |
| title_fullStr | Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccination |
| title_full_unstemmed | Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccination |
| title_short | Severe chickenpox disease and seroprevalence in Sweden – implications for general vaccination |
| title_sort | severe chickenpox disease and seroprevalence in sweden implications for general vaccination |
| topic | Chickenpox Hospitalization Seroepidemiologic studies Seroprevalence |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221006445 |
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