Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

Hotspot mutations of Ras drive cell transformation and tumorigenesis. Less frequent mutations in Ras are poorly characterized for their oncogenic potential. Yet insight into their mechanism of action may point to novel opportunities to target Ras. Here, we show that several cancer-associated mutatio...

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Bibliographic Details
Main Authors: Maja Šolman, Alessio Ligabue, Olga Blaževitš, Alok Jaiswal, Yong Zhou, Hong Liang, Benoit Lectez, Kari Kopra, Camilo Guzmán, Harri Härmä, John F Hancock, Tero Aittokallio, Daniel Abankwa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
Ras
cancer
membrane
nanoclustering
signalling
Online Access:https://elifesciences.org/articles/08905

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