The estimated disease burden of COVID-19 in Japan from 2020 to 2021
Background: To date, it is not fully understood to what extent COVID-19 has burdened society in Japan. This study aimed to estimate the total disease burden due to COVID-19 in Japan during 2020–2021. Methods: We stratify disease burden estimates by age group and present it as absolute Quality Adjust...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034123001806 |
| _version_ | 1797786585622642688 |
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| author | Shinya Tsuzuki Philippe Beutels |
| author_facet | Shinya Tsuzuki Philippe Beutels |
| author_sort | Shinya Tsuzuki |
| collection | DOAJ |
| description | Background: To date, it is not fully understood to what extent COVID-19 has burdened society in Japan. This study aimed to estimate the total disease burden due to COVID-19 in Japan during 2020–2021. Methods: We stratify disease burden estimates by age group and present it as absolute Quality Adjusted Life Years (QALYs) lost and QALYs lost per 100,000 persons. The total estimated value of QALYs lost consists of (1) QALYs lost brought by deaths due to COVID-19, (2) QALYs lost brought by inpatient cases, (3) QALYs lost brought by outpatient cases, and (4) QALYs lost brought by long-COVID. Results: The total QALYs lost due to COVID-19 was estimated as 286,782 for two years, 114.0 QALYs per 100,000 population per year. 71.3% of them were explained by the burden derived from deaths. Probabilistic sensitivity analysis showed that the burden of outpatient cases was the most sensitive factor. Conclusions: The large part of disease burden due to COVID-19 in Japan from the beginning of 2020 to the end of 2021 was derived from Wave 3, 4, and 5 and the proportion of QALYs lost due to morbidity in the total burden increased gradually. The estimated disease burden was smaller than that in other high-income countries. It will be our future challenge to take other indirect factors into consideration. |
| first_indexed | 2024-03-13T01:10:00Z |
| format | Article |
| id | doaj.art-a84e7217e7444a37bf1b45bfc7916e27 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-03-13T01:10:00Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-a84e7217e7444a37bf1b45bfc7916e272023-07-06T04:17:30ZengElsevierJournal of Infection and Public Health1876-03412023-08-0116812361243The estimated disease burden of COVID-19 in Japan from 2020 to 2021Shinya Tsuzuki0Philippe Beutels1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan; Centre for Health Economic Research and Modelling Infectious Diseases, Vaccine & Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; AMR Clinical Reference Center, National Center for Global Health and Medicine, Tokyo, Japan; Correspondence to: National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.Centre for Health Economic Research and Modelling Infectious Diseases, Vaccine & Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumBackground: To date, it is not fully understood to what extent COVID-19 has burdened society in Japan. This study aimed to estimate the total disease burden due to COVID-19 in Japan during 2020–2021. Methods: We stratify disease burden estimates by age group and present it as absolute Quality Adjusted Life Years (QALYs) lost and QALYs lost per 100,000 persons. The total estimated value of QALYs lost consists of (1) QALYs lost brought by deaths due to COVID-19, (2) QALYs lost brought by inpatient cases, (3) QALYs lost brought by outpatient cases, and (4) QALYs lost brought by long-COVID. Results: The total QALYs lost due to COVID-19 was estimated as 286,782 for two years, 114.0 QALYs per 100,000 population per year. 71.3% of them were explained by the burden derived from deaths. Probabilistic sensitivity analysis showed that the burden of outpatient cases was the most sensitive factor. Conclusions: The large part of disease burden due to COVID-19 in Japan from the beginning of 2020 to the end of 2021 was derived from Wave 3, 4, and 5 and the proportion of QALYs lost due to morbidity in the total burden increased gradually. The estimated disease burden was smaller than that in other high-income countries. It will be our future challenge to take other indirect factors into consideration.http://www.sciencedirect.com/science/article/pii/S1876034123001806COVID-19Disease burdenJapan |
| spellingShingle | Shinya Tsuzuki Philippe Beutels The estimated disease burden of COVID-19 in Japan from 2020 to 2021 Journal of Infection and Public Health COVID-19 Disease burden Japan |
| title | The estimated disease burden of COVID-19 in Japan from 2020 to 2021 |
| title_full | The estimated disease burden of COVID-19 in Japan from 2020 to 2021 |
| title_fullStr | The estimated disease burden of COVID-19 in Japan from 2020 to 2021 |
| title_full_unstemmed | The estimated disease burden of COVID-19 in Japan from 2020 to 2021 |
| title_short | The estimated disease burden of COVID-19 in Japan from 2020 to 2021 |
| title_sort | estimated disease burden of covid 19 in japan from 2020 to 2021 |
| topic | COVID-19 Disease burden Japan |
| url | http://www.sciencedirect.com/science/article/pii/S1876034123001806 |
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