Mimics of vascular ischaemia: Rare variant of drug-induced vasculitis and associated autoimmune pathogenicity – A report of two cases
Drug-induced vasculitis is the inflammation of blood vessels instigated by a pharmaceutical agent and can mimic vascular ischaemia. The inflammatory environment can be acute or chronic. Activation of endothelial cells and coagulation factors predisposes a vessel to thrombosis and ischaemia of the ti...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-12-01
|
| Series: | Annals of Vascular Surgery - Brief Reports and Innovations |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772687821000143 |
| _version_ | 1797788404353597440 |
|---|---|
| author | Shirley Cai Animesh Singla Krystal Dinh Vikram Puttaswamy |
| author_facet | Shirley Cai Animesh Singla Krystal Dinh Vikram Puttaswamy |
| author_sort | Shirley Cai |
| collection | DOAJ |
| description | Drug-induced vasculitis is the inflammation of blood vessels instigated by a pharmaceutical agent and can mimic vascular ischaemia. The inflammatory environment can be acute or chronic. Activation of endothelial cells and coagulation factors predisposes a vessel to thrombosis and ischaemia of the tissues and organs it supplies. An element of autoimmune activation may contribute to the pathogenesis and subsequent clinical manifestation of this condition. We report two cases of peripheral limb ischaemia in patients with a history of psychostimulant use and discuss the investigations undertaken and their subsequent management. Diagnosis of drug-induced vasculitis can be challenging, and a wide variety of other differentials must first be explored. Understanding the pathophysiology underlying drug-induced vasculitis and secondary autoimmune thrombophilia allows for better diagnostic and therapeutic management in this rare cohort of patients. |
| first_indexed | 2024-03-13T01:35:08Z |
| format | Article |
| id | doaj.art-a84ed057d7874c689522b08dbb8f7594 |
| institution | Directory Open Access Journal |
| issn | 2772-6878 |
| language | English |
| last_indexed | 2024-03-13T01:35:08Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Vascular Surgery - Brief Reports and Innovations |
| spelling | doaj.art-a84ed057d7874c689522b08dbb8f75942023-07-04T05:11:33ZengElsevierAnnals of Vascular Surgery - Brief Reports and Innovations2772-68782021-12-0112100013Mimics of vascular ischaemia: Rare variant of drug-induced vasculitis and associated autoimmune pathogenicity – A report of two casesShirley Cai0Animesh Singla1Krystal Dinh2Vikram Puttaswamy3Department of Vascular Surgery, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia; Corresponding author.Department of Vascular Surgery, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia; School of Medicine, Western Sydney University, Campbelltown, NSW 2560, AustraliaDepartment of Vascular Surgery, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, AustraliaDepartment of Vascular Surgery, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, AustraliaDrug-induced vasculitis is the inflammation of blood vessels instigated by a pharmaceutical agent and can mimic vascular ischaemia. The inflammatory environment can be acute or chronic. Activation of endothelial cells and coagulation factors predisposes a vessel to thrombosis and ischaemia of the tissues and organs it supplies. An element of autoimmune activation may contribute to the pathogenesis and subsequent clinical manifestation of this condition. We report two cases of peripheral limb ischaemia in patients with a history of psychostimulant use and discuss the investigations undertaken and their subsequent management. Diagnosis of drug-induced vasculitis can be challenging, and a wide variety of other differentials must first be explored. Understanding the pathophysiology underlying drug-induced vasculitis and secondary autoimmune thrombophilia allows for better diagnostic and therapeutic management in this rare cohort of patients.http://www.sciencedirect.com/science/article/pii/S2772687821000143VasculitisDrug induced vasculitisVascular ischaemiaPsychostimulantSympathomimetic |
| spellingShingle | Shirley Cai Animesh Singla Krystal Dinh Vikram Puttaswamy Mimics of vascular ischaemia: Rare variant of drug-induced vasculitis and associated autoimmune pathogenicity – A report of two cases Annals of Vascular Surgery - Brief Reports and Innovations Vasculitis Drug induced vasculitis Vascular ischaemia Psychostimulant Sympathomimetic |
| title | Mimics of vascular ischaemia: Rare variant of drug-induced vasculitis and associated autoimmune pathogenicity – A report of two cases |
| title_full | Mimics of vascular ischaemia: Rare variant of drug-induced vasculitis and associated autoimmune pathogenicity – A report of two cases |
| title_fullStr | Mimics of vascular ischaemia: Rare variant of drug-induced vasculitis and associated autoimmune pathogenicity – A report of two cases |
| title_full_unstemmed | Mimics of vascular ischaemia: Rare variant of drug-induced vasculitis and associated autoimmune pathogenicity – A report of two cases |
| title_short | Mimics of vascular ischaemia: Rare variant of drug-induced vasculitis and associated autoimmune pathogenicity – A report of two cases |
| title_sort | mimics of vascular ischaemia rare variant of drug induced vasculitis and associated autoimmune pathogenicity a report of two cases |
| topic | Vasculitis Drug induced vasculitis Vascular ischaemia Psychostimulant Sympathomimetic |
| url | http://www.sciencedirect.com/science/article/pii/S2772687821000143 |
| work_keys_str_mv | AT shirleycai mimicsofvascularischaemiararevariantofdruginducedvasculitisandassociatedautoimmunepathogenicityareportoftwocases AT animeshsingla mimicsofvascularischaemiararevariantofdruginducedvasculitisandassociatedautoimmunepathogenicityareportoftwocases AT krystaldinh mimicsofvascularischaemiararevariantofdruginducedvasculitisandassociatedautoimmunepathogenicityareportoftwocases AT vikramputtaswamy mimicsofvascularischaemiararevariantofdruginducedvasculitisandassociatedautoimmunepathogenicityareportoftwocases |