Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study.
<h4>Background</h4>Severe Strongyloides stercoralis infection in kidney transplant recipients is associated with considerable morbidity and mortality, although little is known about the risk factors for such infection.<h4>Methodology/principal findings</h4>This was a retrospe...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0007998 |
| _version_ | 1818898931709378560 |
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| author | Lísia Miglioli-Galvão José Osmar Medina Pestana Guilherme Santoro-Lopes Renato Torres Gonçalves Lúcio R Requião Moura Álvaro Pacheco Silva Lígia Camera Pierrotti Elias David Neto Evelyne Santana Girão Cláudia Maria Costa de Oliveira Cely Saad Abboud João Ítalo Dias França Carolina Devite Bittante Luci Corrêa Luís Fernando Aranha Camargo |
| author_facet | Lísia Miglioli-Galvão José Osmar Medina Pestana Guilherme Santoro-Lopes Renato Torres Gonçalves Lúcio R Requião Moura Álvaro Pacheco Silva Lígia Camera Pierrotti Elias David Neto Evelyne Santana Girão Cláudia Maria Costa de Oliveira Cely Saad Abboud João Ítalo Dias França Carolina Devite Bittante Luci Corrêa Luís Fernando Aranha Camargo |
| author_sort | Lísia Miglioli-Galvão |
| collection | DOAJ |
| description | <h4>Background</h4>Severe Strongyloides stercoralis infection in kidney transplant recipients is associated with considerable morbidity and mortality, although little is known about the risk factors for such infection.<h4>Methodology/principal findings</h4>This was a retrospective, multicenter, case-control study in which we assessed the risk factors for and clinical outcomes of severe S. stercoralis infections in kidney transplant recipients in Brazil. We included 138 kidney transplant recipients: 46 cases and 92 controls. Among the cases, the median number of days from transplantation to diagnosis was 117 (interquartile range [IQR], 73.5-965) and the most common clinical findings were gastrointestinal symptoms (in 78.3%) and respiratory symptoms (in 39.1%), whereas fever and eosinophilia were seen in only 32.6% and 43.5%, respectively. The 30-day all-cause mortality among the cases was 28.3% overall and was significantly higher among the cases of infection occurring within the first three months after transplantation (47% vs. 17.2%, P = 0.04). The independent risk factors were receiving a transplant from a deceased donor (odds ratio [OR] = 6.16, 95% confidence interval [CI] = 2.05-18.5), a history of bacterial infection (OR = 3.04, 95% CI = 1.2-7.5), and a cumulative corticosteroid dose (OR = 1.005, 95% CI = 1.001-1.009). The independent predictors of mortality were respiratory failure (OR = 98.33, 95% CI = 4.46-2169.77) and concomitant bacteremia (OR = 413.00, 95% CI = 4.83-35316.61).<h4>Conclusions/significance</h4>Severe S. stercoralis infections are associated with considerable morbidity and mortality after kidney transplantation. In endemic areas, such infection may occur late after transplantation, although it seems to be more severe when it occurs earlier after transplantation. Specific risk factors and clinical manifestations can identify patients at risk, who should receive prophylaxis or early treatment. |
| first_indexed | 2024-12-19T19:39:55Z |
| format | Article |
| id | doaj.art-a8500d75317d4087800af36ff5b187d1 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-19T19:39:55Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-a8500d75317d4087800af36ff5b187d12022-12-21T20:08:18ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352020-01-01141e000799810.1371/journal.pntd.0007998Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study.Lísia Miglioli-GalvãoJosé Osmar Medina PestanaGuilherme Santoro-LopesRenato Torres GonçalvesLúcio R Requião MouraÁlvaro Pacheco SilvaLígia Camera PierrottiElias David NetoEvelyne Santana GirãoCláudia Maria Costa de OliveiraCely Saad AbboudJoão Ítalo Dias FrançaCarolina Devite BittanteLuci CorrêaLuís Fernando Aranha Camargo<h4>Background</h4>Severe Strongyloides stercoralis infection in kidney transplant recipients is associated with considerable morbidity and mortality, although little is known about the risk factors for such infection.<h4>Methodology/principal findings</h4>This was a retrospective, multicenter, case-control study in which we assessed the risk factors for and clinical outcomes of severe S. stercoralis infections in kidney transplant recipients in Brazil. We included 138 kidney transplant recipients: 46 cases and 92 controls. Among the cases, the median number of days from transplantation to diagnosis was 117 (interquartile range [IQR], 73.5-965) and the most common clinical findings were gastrointestinal symptoms (in 78.3%) and respiratory symptoms (in 39.1%), whereas fever and eosinophilia were seen in only 32.6% and 43.5%, respectively. The 30-day all-cause mortality among the cases was 28.3% overall and was significantly higher among the cases of infection occurring within the first three months after transplantation (47% vs. 17.2%, P = 0.04). The independent risk factors were receiving a transplant from a deceased donor (odds ratio [OR] = 6.16, 95% confidence interval [CI] = 2.05-18.5), a history of bacterial infection (OR = 3.04, 95% CI = 1.2-7.5), and a cumulative corticosteroid dose (OR = 1.005, 95% CI = 1.001-1.009). The independent predictors of mortality were respiratory failure (OR = 98.33, 95% CI = 4.46-2169.77) and concomitant bacteremia (OR = 413.00, 95% CI = 4.83-35316.61).<h4>Conclusions/significance</h4>Severe S. stercoralis infections are associated with considerable morbidity and mortality after kidney transplantation. In endemic areas, such infection may occur late after transplantation, although it seems to be more severe when it occurs earlier after transplantation. Specific risk factors and clinical manifestations can identify patients at risk, who should receive prophylaxis or early treatment.https://doi.org/10.1371/journal.pntd.0007998 |
| spellingShingle | Lísia Miglioli-Galvão José Osmar Medina Pestana Guilherme Santoro-Lopes Renato Torres Gonçalves Lúcio R Requião Moura Álvaro Pacheco Silva Lígia Camera Pierrotti Elias David Neto Evelyne Santana Girão Cláudia Maria Costa de Oliveira Cely Saad Abboud João Ítalo Dias França Carolina Devite Bittante Luci Corrêa Luís Fernando Aranha Camargo Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study. PLoS Neglected Tropical Diseases |
| title | Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study. |
| title_full | Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study. |
| title_fullStr | Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study. |
| title_full_unstemmed | Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study. |
| title_short | Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study. |
| title_sort | severe strongyloides stercoralis infection in kidney transplant recipients a multicenter case control study |
| url | https://doi.org/10.1371/journal.pntd.0007998 |
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