Oral manifestations of amyloidosis in a multiple myeloma patient: A case report
The term amyloidosis refers to a wide range of diseases in which amorphous, extracellular, eosinophilic proteinaceous deposits form at various locations. In this article, we describe a case of amyloidosis with multiple myeloma in which the oral symptoms of the disease served as the main diagnostic c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-06-01
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| Series: | Acta Marisiensis - Seria Medica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/amma-2023-0019 |
| _version_ | 1797788962066006016 |
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| author | Sadaksharam Jayachandran Priya Sophia Jeba Subramaniam Sripriya Muralidharan Archana |
| author_facet | Sadaksharam Jayachandran Priya Sophia Jeba Subramaniam Sripriya Muralidharan Archana |
| author_sort | Sadaksharam Jayachandran |
| collection | DOAJ |
| description | The term amyloidosis refers to a wide range of diseases in which amorphous, extracellular, eosinophilic proteinaceous deposits form at various locations. In this article, we describe a case of amyloidosis with multiple myeloma in which the oral symptoms of the disease served as the main diagnostic clues. A male patient in his early 60s who had multiple tongue swellings presented to our department. Following an incisional biopsy, histological analysis revealed the presence of eosinophilic, amorphous hyaline-like material that was positive for Congo red staining and was indicative of amyloidosis. The presence of abnormal plasma cells in the patient’s bone marrow aspiration after the biopsy was done was suggestive of multiple myeloma. The patient is currently undergoing the CyBorD (Cyclophosphamide, Bortezomib, and Dexamethasone) treatment for multiple myeloma that has just been diagnosed. We offer this instance to demonstrate that, although uncommon, amyloidosis can initially only manifest as numerous swellings on the tongue. |
| first_indexed | 2024-03-13T01:43:56Z |
| format | Article |
| id | doaj.art-a8503ef0fca9493e8cbf2d3e32498a16 |
| institution | Directory Open Access Journal |
| issn | 2668-7763 |
| language | English |
| last_indexed | 2024-03-13T01:43:56Z |
| publishDate | 2023-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Marisiensis - Seria Medica |
| spelling | doaj.art-a8503ef0fca9493e8cbf2d3e32498a162023-07-03T10:20:59ZengSciendoActa Marisiensis - Seria Medica2668-77632023-06-0169213113410.2478/amma-2023-0019Oral manifestations of amyloidosis in a multiple myeloma patient: A case reportSadaksharam Jayachandran0Priya Sophia Jeba1Subramaniam Sripriya2Muralidharan Archana31Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Chennai, India1Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Chennai, India1Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Chennai, India2Department Oral Medicine and Radiology, Manipal College of Dental Science Mangalore, Manipal Academy of Higher Education, Manipal, IndiaThe term amyloidosis refers to a wide range of diseases in which amorphous, extracellular, eosinophilic proteinaceous deposits form at various locations. In this article, we describe a case of amyloidosis with multiple myeloma in which the oral symptoms of the disease served as the main diagnostic clues. A male patient in his early 60s who had multiple tongue swellings presented to our department. Following an incisional biopsy, histological analysis revealed the presence of eosinophilic, amorphous hyaline-like material that was positive for Congo red staining and was indicative of amyloidosis. The presence of abnormal plasma cells in the patient’s bone marrow aspiration after the biopsy was done was suggestive of multiple myeloma. The patient is currently undergoing the CyBorD (Cyclophosphamide, Bortezomib, and Dexamethasone) treatment for multiple myeloma that has just been diagnosed. We offer this instance to demonstrate that, although uncommon, amyloidosis can initially only manifest as numerous swellings on the tongue.https://doi.org/10.2478/amma-2023-0019amyloidosismultiple myelomatongueamyloid |
| spellingShingle | Sadaksharam Jayachandran Priya Sophia Jeba Subramaniam Sripriya Muralidharan Archana Oral manifestations of amyloidosis in a multiple myeloma patient: A case report Acta Marisiensis - Seria Medica amyloidosis multiple myeloma tongue amyloid |
| title | Oral manifestations of amyloidosis in a multiple myeloma patient: A case report |
| title_full | Oral manifestations of amyloidosis in a multiple myeloma patient: A case report |
| title_fullStr | Oral manifestations of amyloidosis in a multiple myeloma patient: A case report |
| title_full_unstemmed | Oral manifestations of amyloidosis in a multiple myeloma patient: A case report |
| title_short | Oral manifestations of amyloidosis in a multiple myeloma patient: A case report |
| title_sort | oral manifestations of amyloidosis in a multiple myeloma patient a case report |
| topic | amyloidosis multiple myeloma tongue amyloid |
| url | https://doi.org/10.2478/amma-2023-0019 |
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