The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats
Background: Cardiorespiratory fitness improves and the risk of cardiovascular diseases decreases through regular exercise. However, the exact mechanism is unclear. The aim of this study was to investigate the effects of resistance training on some plasma angiogenic factors in normal rats. Methods:...
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| Format: | Article |
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Isfahan University of Medical Sciences
2012-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1649 |
| _version_ | 1797762210670313472 |
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| author | Parivash Shekarchizadeh Majid Khazaei Reza Gharakhanlou Jahangir Karimian Ali Reza Safarzadeh |
| author_facet | Parivash Shekarchizadeh Majid Khazaei Reza Gharakhanlou Jahangir Karimian Ali Reza Safarzadeh |
| author_sort | Parivash Shekarchizadeh |
| collection | DOAJ |
| description | Background: Cardiorespiratory fitness improves and the risk of cardiovascular diseases decreases through regular exercise. However, the exact mechanism is unclear. The aim of this study was to investigate the effects of resistance training on some plasma angiogenic factors in normal rats.
Methods: Twenty male Wistar rats were divided into two groups of control and trained (n = 10 each). The rats in the trained group undertook one training session per day, 3 days a week, for 4 weeks. Blood samples were taken and plasma glucose, lipid profile, nitric oxide (NO), vascular endothelial growth factor (VEGF) and soluble form of VEGF receptor-1 (sFlt-1) concentrations were determined.
Findings: Differences in plasma insulin, glucose, and NO were not significant between the trained and control groups (P ˃ 0.05). Plasma VEGF concentrations were 142.73 ± 3.74 pg/ml and 144.5 ± 5.1 pg/ml in the control and trained rats (P > 0.05), i.e. resistance training did not significantly change plasma VEGF in trained rats. There were no significant differences in plasma sFlt-1 concentrations between the two groups (P ˃ 0.05). Moreover, resistance training could not change VEGF/sFlt-1 ratio in the two groups of animals.
Conclusion: Present data showed that resistance training could not be an effective approach to improve plasma angiogenic factors (NO, VEGF, VEGF receptor-1) at least in healthy rats. More research is needed to show the effects of resistance training on angiogenesis.
Keywords: Nitric oxide, Vascular endothelial growth factor, VEGF receptor-1 (sFlt-1), Resistance training |
| first_indexed | 2024-03-12T19:24:02Z |
| format | Article |
| id | doaj.art-a85363c7b4e3442ab9d4255bee94fc01 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T19:24:02Z |
| publishDate | 2012-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-a85363c7b4e3442ab9d4255bee94fc012023-08-02T04:57:39ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-03-0130176920The Effects of Resistance Training on Plasma Angiogenic Factors in Normal RatsParivash Shekarchizadeh0Majid Khazaei1Reza Gharakhanlou2Jahangir Karimian3Ali Reza Safarzadeh4Lecturer, Department of Physical Education and Sport Sciences, School of Physical Education, Isfahan university of Medical sciences and PhD Student, Department of Exercise Physiology, Tarbiat Modarress University, Tehran, IranMD, PhD, Associate Professor of Medical Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.Associate Professor, Department of Physical Education and Sport Sciences, Tarbiat Modarress University, Tehran, IranAssociate Professor, Department of Physical Education and Sport Sciences, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Exercise Physiology, Tarbiat Modarress University, Tehran, IranBackground: Cardiorespiratory fitness improves and the risk of cardiovascular diseases decreases through regular exercise. However, the exact mechanism is unclear. The aim of this study was to investigate the effects of resistance training on some plasma angiogenic factors in normal rats. Methods: Twenty male Wistar rats were divided into two groups of control and trained (n = 10 each). The rats in the trained group undertook one training session per day, 3 days a week, for 4 weeks. Blood samples were taken and plasma glucose, lipid profile, nitric oxide (NO), vascular endothelial growth factor (VEGF) and soluble form of VEGF receptor-1 (sFlt-1) concentrations were determined. Findings: Differences in plasma insulin, glucose, and NO were not significant between the trained and control groups (P ˃ 0.05). Plasma VEGF concentrations were 142.73 ± 3.74 pg/ml and 144.5 ± 5.1 pg/ml in the control and trained rats (P > 0.05), i.e. resistance training did not significantly change plasma VEGF in trained rats. There were no significant differences in plasma sFlt-1 concentrations between the two groups (P ˃ 0.05). Moreover, resistance training could not change VEGF/sFlt-1 ratio in the two groups of animals. Conclusion: Present data showed that resistance training could not be an effective approach to improve plasma angiogenic factors (NO, VEGF, VEGF receptor-1) at least in healthy rats. More research is needed to show the effects of resistance training on angiogenesis. Keywords: Nitric oxide, Vascular endothelial growth factor, VEGF receptor-1 (sFlt-1), Resistance traininghttp://jims.mui.ac.ir/index.php/jims/article/view/1649 |
| spellingShingle | Parivash Shekarchizadeh Majid Khazaei Reza Gharakhanlou Jahangir Karimian Ali Reza Safarzadeh The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats مجله دانشکده پزشکی اصفهان |
| title | The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats |
| title_full | The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats |
| title_fullStr | The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats |
| title_full_unstemmed | The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats |
| title_short | The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats |
| title_sort | effects of resistance training on plasma angiogenic factors in normal rats |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/1649 |
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