Microscopic polyangiitis: Modern concepts and treatment options

Microscopic polyangiitis: Modern concepts and treatment options

The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is v...

Full description

Bibliographic Details
Main Authors: I. T. Murkamilov, K. A. Aitbaev, V. V. Fomin, I. O. Kudaibergenova, F. A. Yusupov, Zh. A. Murkamilova, T. V. Beketova
Format: Article
Language:Russian
Published: IMA PRESS LLC 2021-10-01
Series:Научно-практическая ревматология
Subjects:
systemic vasculitis
anca
microscopic polyangiitis
glomerulonephritis
alveolitis
myeloperoxidase
proteinase 3
glucocorticosteroids
rituximab
cytostatics
Online Access:https://rsp.mediar-press.net/rsp/article/view/3082
Description
Summary:The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is very common and pulmonary capillaritis often occurs. MPA can cause rapidly progressive damage to organ systems. The modern possibilities of MPA treatment, primarily anti-B cell therapy with rituximab, are discussed.
ISSN:1995-4484
1995-4492

Similar Items