Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B Irradiation
Medicinal plants have long been used as a source of therapeutic agents. They are thought to be important anti-aging ingredients in prophylactic medicines. The aim of this study was to screen extracts from Taiwanese plant materials for phenolic contents and measure the corresponding matrix metallopro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/14/3/1062/ |
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| author | Yueh-Lun Lee Mei-Hsien Lee Hsiu-Ju Chang Po-Yuan Huang I-Jen Huang Kur-Ta Cheng Sy-Jye Leu |
| author_facet | Yueh-Lun Lee Mei-Hsien Lee Hsiu-Ju Chang Po-Yuan Huang I-Jen Huang Kur-Ta Cheng Sy-Jye Leu |
| author_sort | Yueh-Lun Lee |
| collection | DOAJ |
| description | Medicinal plants have long been used as a source of therapeutic agents. They are thought to be important anti-aging ingredients in prophylactic medicines. The aim of this study was to screen extracts from Taiwanese plant materials for phenolic contents and measure the corresponding matrix metalloproteinase-9 (MMP-9) activity. We extracted biological ingredients from eight plants native to Taiwan (Alnus formosana, Diospyros discolor, Eriobotrya deflex, Machilus japonica, Pyrrosia polydactylis, Pyrus taiwanensis, Vitis adstricta, Vitis thunbergii). Total phenolic content was measured using the Folin-Ciocalteu method. MMP-9 activities were measured by gelatin zymography. The extracted yields of plants ranged from 3.7 % to 16.9 %. The total phenolic contents ranged from 25.4 to 36.8 mg GAE/g dry material. All of these extracts (except Vitis adstricta Hance) were shown to inhibit MMP-9 activity of WS-1 cell after ultraviolet B irradiation. These findings suggest that total phenolic content may influence MMP-9 activity and that some of the plants with higher phenolic content exhibited various biological activities that could serve as potent inhibitors of the ageing process in the skin. This property might be useful in the production of cosmetics. |
| first_indexed | 2024-12-11T09:35:33Z |
| format | Article |
| id | doaj.art-a8543b92dd324550a83e0de1456142c0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T09:35:33Z |
| publishDate | 2009-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a8543b92dd324550a83e0de1456142c02022-12-22T01:12:53ZengMDPI AGMolecules1420-30492009-03-011431062107110.3390/molecules14031062Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B IrradiationYueh-Lun LeeMei-Hsien LeeHsiu-Ju ChangPo-Yuan HuangI-Jen HuangKur-Ta ChengSy-Jye LeuMedicinal plants have long been used as a source of therapeutic agents. They are thought to be important anti-aging ingredients in prophylactic medicines. The aim of this study was to screen extracts from Taiwanese plant materials for phenolic contents and measure the corresponding matrix metalloproteinase-9 (MMP-9) activity. We extracted biological ingredients from eight plants native to Taiwan (Alnus formosana, Diospyros discolor, Eriobotrya deflex, Machilus japonica, Pyrrosia polydactylis, Pyrus taiwanensis, Vitis adstricta, Vitis thunbergii). Total phenolic content was measured using the Folin-Ciocalteu method. MMP-9 activities were measured by gelatin zymography. The extracted yields of plants ranged from 3.7 % to 16.9 %. The total phenolic contents ranged from 25.4 to 36.8 mg GAE/g dry material. All of these extracts (except Vitis adstricta Hance) were shown to inhibit MMP-9 activity of WS-1 cell after ultraviolet B irradiation. These findings suggest that total phenolic content may influence MMP-9 activity and that some of the plants with higher phenolic content exhibited various biological activities that could serve as potent inhibitors of the ageing process in the skin. This property might be useful in the production of cosmetics.http://www.mdpi.com/1420-3049/14/3/1062/Taiwanese native plantPolyphenolicMatrix metalloproteinase-9 |
| spellingShingle | Yueh-Lun Lee Mei-Hsien Lee Hsiu-Ju Chang Po-Yuan Huang I-Jen Huang Kur-Ta Cheng Sy-Jye Leu Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B Irradiation Molecules Taiwanese native plant Polyphenolic Matrix metalloproteinase-9 |
| title | Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B Irradiation |
| title_full | Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B Irradiation |
| title_fullStr | Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B Irradiation |
| title_full_unstemmed | Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B Irradiation |
| title_short | Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B Irradiation |
| title_sort | taiwanese native plants inhibit matrix metalloproteinase 9 activity after ultraviolet b irradiation |
| topic | Taiwanese native plant Polyphenolic Matrix metalloproteinase-9 |
| url | http://www.mdpi.com/1420-3049/14/3/1062/ |
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