Urinary estrogen metabolites and gastric cancer risk among postmenopausal women
Abstract Background The overall incidence of gastric cancer in women is half that in men for most global populations. Sex hormone pathways may be involved in carcinogenesis and estrogens have been postulated to protect women against gastric cancer. Aim To evaluate associations of gastric cancer with...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-07-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1574 |
| _version_ | 1828776757136719872 |
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| author | M. Constanza Camargo Minkyo Song Xia Xu Isaac Zhao Joshua N. Sampson Arash Etemadi Hermann Brenner Hwi‐Won Lee Britton Trabert Bernd Holleczek Ben Schöttker Kathleen Spaid Sanford M. Dawsey Sangjun Lee Takaya Shimura Sue K. Park Reza Malekzadeh Daehee Kang Charles S. Rabkin |
| author_facet | M. Constanza Camargo Minkyo Song Xia Xu Isaac Zhao Joshua N. Sampson Arash Etemadi Hermann Brenner Hwi‐Won Lee Britton Trabert Bernd Holleczek Ben Schöttker Kathleen Spaid Sanford M. Dawsey Sangjun Lee Takaya Shimura Sue K. Park Reza Malekzadeh Daehee Kang Charles S. Rabkin |
| author_sort | M. Constanza Camargo |
| collection | DOAJ |
| description | Abstract Background The overall incidence of gastric cancer in women is half that in men for most global populations. Sex hormone pathways may be involved in carcinogenesis and estrogens have been postulated to protect women against gastric cancer. Aim To evaluate associations of gastric cancer with estrogen metabolites in postmenopausal women. Methods and results We performed an analysis of 233 gastric cancer cases and 281 age‐matched controls from three prospective cohorts and two case‐control studies of early‐stage gastric cancer, mainly conducted in high‐risk Asian populations. Fifteen estrogen‐parent (estrone and estradiol) and ‐metabolite analytes (2‐hydroxyestrone, 2‐hydroxyestradiol, 2‐hydroxyestrone‐3‐methyl ether, 4‐hydroxyestrone; 4‐methoxyestrone, 4‐methoxyestradiol, 2‐methoxyestrone, 2‐methoxyestradiol, estriol, 16α‐hydroxyestrone, 16‐ketoestradiol, 16‐epiestriol, and 17‐epiestriol) were measured in spot urines using liquid chromatography–tandem mass spectrometry. Odds ratios for association with each marker were estimated by logistic regression. Heterogeneity was assessed by Cochran's Q test. Study‐specific odds ratios were pooled by fixed‐effects meta‐analysis. Urinary levels of estrogen‐related molecules were not associated with gastric cancer (adjusted odds ratios ranged from 0.87 to 1.27; p‐values >.05), with low between‐study heterogeneity (p‐values >.1) for all but two metabolites (2‐hydroxyestrone‐3‐methyl ether and 2‐methoxyestradiol). Conclusion To date, this is the first comprehensive assessment of endogenous estrogens with gastric cancer risk in women. Estrogens do not appear to have an etiologic role in gastric cancer risk among postmenopausal women. Given the complex network of sex steroid hormones and their extreme variation over the lifespan, further evaluation of this hypothesis is warranted. |
| first_indexed | 2024-12-11T16:05:44Z |
| format | Article |
| id | doaj.art-a8548b46326046b08e27263b48386b43 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-12-11T16:05:44Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-a8548b46326046b08e27263b48386b432022-12-22T00:59:12ZengWileyCancer Reports2573-83482022-07-0157n/an/a10.1002/cnr2.1574Urinary estrogen metabolites and gastric cancer risk among postmenopausal womenM. Constanza Camargo0Minkyo Song1Xia Xu2Isaac Zhao3Joshua N. Sampson4Arash Etemadi5Hermann Brenner6Hwi‐Won Lee7Britton Trabert8Bernd Holleczek9Ben Schöttker10Kathleen Spaid11Sanford M. Dawsey12Sangjun Lee13Takaya Shimura14Sue K. Park15Reza Malekzadeh16Daehee Kang17Charles S. Rabkin18Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USADivision of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USACancer Research Technology Program, Leidos Biomedical Research, Inc. Frederick National Laboratory for Cancer Research Frederick Maryland USADivision of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USADivision of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USADivision of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USADivision of Preventive Oncology German Cancer Research Center and National Center for Tumor Diseases Heidelberg GermanyDepartment of Preventive Medicine Seoul National University College of Medicine Seoul South KoreaDivision of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USADivision of Clinical Epidemiology and Ageing Research German Cancer Research Center Heidelberg GermanyDivision of Clinical Epidemiology and Ageing Research German Cancer Research Center Heidelberg GermanyDepartment of Laboratory Medicine, Clinical Center National Institutes of Health Bethesda Maryland USADivision of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USADepartment of Preventive Medicine Seoul National University College of Medicine Seoul South KoreaDepartment of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Preventive Medicine Seoul National University College of Medicine Seoul South KoreaDigestive Disease Research Center, Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran IranDepartment of Preventive Medicine Seoul National University College of Medicine Seoul South KoreaDivision of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USAAbstract Background The overall incidence of gastric cancer in women is half that in men for most global populations. Sex hormone pathways may be involved in carcinogenesis and estrogens have been postulated to protect women against gastric cancer. Aim To evaluate associations of gastric cancer with estrogen metabolites in postmenopausal women. Methods and results We performed an analysis of 233 gastric cancer cases and 281 age‐matched controls from three prospective cohorts and two case‐control studies of early‐stage gastric cancer, mainly conducted in high‐risk Asian populations. Fifteen estrogen‐parent (estrone and estradiol) and ‐metabolite analytes (2‐hydroxyestrone, 2‐hydroxyestradiol, 2‐hydroxyestrone‐3‐methyl ether, 4‐hydroxyestrone; 4‐methoxyestrone, 4‐methoxyestradiol, 2‐methoxyestrone, 2‐methoxyestradiol, estriol, 16α‐hydroxyestrone, 16‐ketoestradiol, 16‐epiestriol, and 17‐epiestriol) were measured in spot urines using liquid chromatography–tandem mass spectrometry. Odds ratios for association with each marker were estimated by logistic regression. Heterogeneity was assessed by Cochran's Q test. Study‐specific odds ratios were pooled by fixed‐effects meta‐analysis. Urinary levels of estrogen‐related molecules were not associated with gastric cancer (adjusted odds ratios ranged from 0.87 to 1.27; p‐values >.05), with low between‐study heterogeneity (p‐values >.1) for all but two metabolites (2‐hydroxyestrone‐3‐methyl ether and 2‐methoxyestradiol). Conclusion To date, this is the first comprehensive assessment of endogenous estrogens with gastric cancer risk in women. Estrogens do not appear to have an etiologic role in gastric cancer risk among postmenopausal women. Given the complex network of sex steroid hormones and their extreme variation over the lifespan, further evaluation of this hypothesis is warranted.https://doi.org/10.1002/cnr2.1574estradiolestrogensestronegastric cancersex hormones |
| spellingShingle | M. Constanza Camargo Minkyo Song Xia Xu Isaac Zhao Joshua N. Sampson Arash Etemadi Hermann Brenner Hwi‐Won Lee Britton Trabert Bernd Holleczek Ben Schöttker Kathleen Spaid Sanford M. Dawsey Sangjun Lee Takaya Shimura Sue K. Park Reza Malekzadeh Daehee Kang Charles S. Rabkin Urinary estrogen metabolites and gastric cancer risk among postmenopausal women Cancer Reports estradiol estrogens estrone gastric cancer sex hormones |
| title | Urinary estrogen metabolites and gastric cancer risk among postmenopausal women |
| title_full | Urinary estrogen metabolites and gastric cancer risk among postmenopausal women |
| title_fullStr | Urinary estrogen metabolites and gastric cancer risk among postmenopausal women |
| title_full_unstemmed | Urinary estrogen metabolites and gastric cancer risk among postmenopausal women |
| title_short | Urinary estrogen metabolites and gastric cancer risk among postmenopausal women |
| title_sort | urinary estrogen metabolites and gastric cancer risk among postmenopausal women |
| topic | estradiol estrogens estrone gastric cancer sex hormones |
| url | https://doi.org/10.1002/cnr2.1574 |
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