Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition

Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition

Glycosylation of IgG regulates the effector function of this antibody in the immune response. Glycosylated IgG is a potent therapeutic used for both research and clinical purposes. While there is ample research on how different cell culture conditions affect IgG glycosylation, the data are missing o...

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Bibliographic Details
Main Authors: Fran Lukšić, Anika Mijakovac, Goran Josipović, Vedrana Vičić Bočkor, Jasminka Krištić, Ana Cindrić, Martina Vinicki, Filip Rokić, Oliver Vugrek, Gordan Lauc, Vlatka Zoldoš
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomolecules
Subjects:
IgG glycosylation
long-term cell culturing
FreeStyle 293-F
IgG glycoengineering
cell aging
Online Access:https://www.mdpi.com/2218-273X/13/8/1245

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