Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic Target
BTB and CNC homology1 (BACH1), working as a transcriptional factor, is demonstrated to function on the regulation of epigenetic modifications by complex regulatory networks. Although BACH1 is reported as an oncogene, the overall analysis of its role remains lacking. In this study, we uncovered the c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.920911/full |
| _version_ | 1811235367852965888 |
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| author | Zheming Liu Jing Wang Huiyong Chen Zankai Wu Fuben Liao Sheng Wang Ting Zhu |
| author_facet | Zheming Liu Jing Wang Huiyong Chen Zankai Wu Fuben Liao Sheng Wang Ting Zhu |
| author_sort | Zheming Liu |
| collection | DOAJ |
| description | BTB and CNC homology1 (BACH1), working as a transcriptional factor, is demonstrated to function on the regulation of epigenetic modifications by complex regulatory networks. Although BACH1 is reported as an oncogene, the overall analysis of its role remains lacking. In this study, we uncovered the capacity of BACH1 as a new pan-cancer therapeutic target. We found that BACH1 is highly expressed in abundant cancers and correlated with the poor prognosis of most cancers. The mutation sites of BACH1 varied in different cancer types and correlated to patients’ prognoses. The tumor mutation burden (TMB) in four cancer species and up to six tumor infiltrated immune cells had a significant relevance with BACH1. The enrichment analysis showed that the BACH1-associated genes were significantly enriched in the pathways of PD-1/L1 expression, ubiquitin-mediated proteolysis, T cell receptor, Th17 cell differentiation. We then demonstrated that BACH1 is positively correlated with the expression of many candidate genes, incluing SRPK2, GCLM, SLC40A1, and HK2 but negatively correlated with the expression of KEAP1 and GAPDH. Overall, our data shed light on BACH1’s effect on latent utility in cancer targeting therapy. |
| first_indexed | 2024-04-12T11:49:39Z |
| format | Article |
| id | doaj.art-a855e676b77348a6bb2125e97a597389 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T11:49:39Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-a855e676b77348a6bb2125e97a5973892022-12-22T03:34:14ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-05-011310.3389/fgene.2022.920911920911Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic TargetZheming Liu0Jing Wang1Huiyong Chen2Zankai Wu3Fuben Liao4Sheng Wang5Ting Zhu6Cancer Center, Renmin Hospital of Wuhan University, Wuhan, ChinaReproductive Medicine Centre, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaCancer Center, Renmin Hospital of Wuhan University, Wuhan, ChinaInstitutes of Biomedical Sciences, Fudan University, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaBTB and CNC homology1 (BACH1), working as a transcriptional factor, is demonstrated to function on the regulation of epigenetic modifications by complex regulatory networks. Although BACH1 is reported as an oncogene, the overall analysis of its role remains lacking. In this study, we uncovered the capacity of BACH1 as a new pan-cancer therapeutic target. We found that BACH1 is highly expressed in abundant cancers and correlated with the poor prognosis of most cancers. The mutation sites of BACH1 varied in different cancer types and correlated to patients’ prognoses. The tumor mutation burden (TMB) in four cancer species and up to six tumor infiltrated immune cells had a significant relevance with BACH1. The enrichment analysis showed that the BACH1-associated genes were significantly enriched in the pathways of PD-1/L1 expression, ubiquitin-mediated proteolysis, T cell receptor, Th17 cell differentiation. We then demonstrated that BACH1 is positively correlated with the expression of many candidate genes, incluing SRPK2, GCLM, SLC40A1, and HK2 but negatively correlated with the expression of KEAP1 and GAPDH. Overall, our data shed light on BACH1’s effect on latent utility in cancer targeting therapy.https://www.frontiersin.org/articles/10.3389/fgene.2022.920911/fullBTB and CNC homology1 (BACH1)therapeutic targettumor mutation burdenimmune cell infiltrationmetabolism |
| spellingShingle | Zheming Liu Jing Wang Huiyong Chen Zankai Wu Fuben Liao Sheng Wang Ting Zhu Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic Target Frontiers in Genetics BTB and CNC homology1 (BACH1) therapeutic target tumor mutation burden immune cell infiltration metabolism |
| title | Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic Target |
| title_full | Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic Target |
| title_fullStr | Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic Target |
| title_full_unstemmed | Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic Target |
| title_short | Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic Target |
| title_sort | uncovering btb and cnc homology1 bach1 as a novel cancer therapeutic target |
| topic | BTB and CNC homology1 (BACH1) therapeutic target tumor mutation burden immune cell infiltration metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.920911/full |
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