Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation
The ability to detect and respond appropriately to aversive stimuli is essential for all organisms, from fruit flies to humans. This suggests the existence of a core neural network which mediates aversion-related processing. Human imaging studies on aversion have highlighted the involvement of vario...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2011-10-01
|
| Series: | Frontiers in Integrative Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnint.2011.00049/full |
| _version_ | 1818059165132652544 |
|---|---|
| author | Dave J Hayes Georg eNorthoff |
| author_facet | Dave J Hayes Georg eNorthoff |
| author_sort | Dave J Hayes |
| collection | DOAJ |
| description | The ability to detect and respond appropriately to aversive stimuli is essential for all organisms, from fruit flies to humans. This suggests the existence of a core neural network which mediates aversion-related processing. Human imaging studies on aversion have highlighted the involvement of various cortical regions, such as the prefrontal cortex, while animal studies have focused largely on subcortical regions like the periaqueductal gray and hypothalamus. However, whether and how these regions form a core neural network of aversion remains unclear. To help determine this, a translational cross-species investigation in humans (i.e. meta-analysis) and other animals (i.e. systematic review of functional neuroanatomy) was performed. Our results highlighted the recruitment of the anterior cingulate cortex, the anterior insula, and the amygdala as well as other subcortical (e.g. thalalmus, midbrain) and cortical (e.g. orbitofrontal) regions in both animals and humans. Importantly, involvement of these regions remained independent of sensory modality. This study provides evidence for a core neural network mediating aversion in both animals and humans. This not only contributes to our understanding of the trans-species neural correlates of aversion but may also carry important implications for psychiatric disorders where abnormal aversive behaviour can often be observed. |
| first_indexed | 2024-12-10T13:12:11Z |
| format | Article |
| id | doaj.art-a855ec5af3094ead8e0fc4a9fe4d030f |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-12-10T13:12:11Z |
| publishDate | 2011-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-a855ec5af3094ead8e0fc4a9fe4d030f2022-12-22T01:47:39ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452011-10-01510.3389/fnint.2011.0004912950Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigationDave J Hayes0Georg eNorthoff1University of Ottawa, Institute of Mental Health ResearchUniversity of Ottawa, Institute of Mental Health ResearchThe ability to detect and respond appropriately to aversive stimuli is essential for all organisms, from fruit flies to humans. This suggests the existence of a core neural network which mediates aversion-related processing. Human imaging studies on aversion have highlighted the involvement of various cortical regions, such as the prefrontal cortex, while animal studies have focused largely on subcortical regions like the periaqueductal gray and hypothalamus. However, whether and how these regions form a core neural network of aversion remains unclear. To help determine this, a translational cross-species investigation in humans (i.e. meta-analysis) and other animals (i.e. systematic review of functional neuroanatomy) was performed. Our results highlighted the recruitment of the anterior cingulate cortex, the anterior insula, and the amygdala as well as other subcortical (e.g. thalalmus, midbrain) and cortical (e.g. orbitofrontal) regions in both animals and humans. Importantly, involvement of these regions remained independent of sensory modality. This study provides evidence for a core neural network mediating aversion in both animals and humans. This not only contributes to our understanding of the trans-species neural correlates of aversion but may also carry important implications for psychiatric disorders where abnormal aversive behaviour can often be observed.http://journal.frontiersin.org/Journal/10.3389/fnint.2011.00049/fullimagingMeta-analysisAnimal ModelstranslationalAversion |
| spellingShingle | Dave J Hayes Georg eNorthoff Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation Frontiers in Integrative Neuroscience imaging Meta-analysis Animal Models translational Aversion |
| title | Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation |
| title_full | Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation |
| title_fullStr | Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation |
| title_full_unstemmed | Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation |
| title_short | Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation |
| title_sort | identifying a network of brain regions involved in aversion related processing a cross species translational investigation |
| topic | imaging Meta-analysis Animal Models translational Aversion |
| url | http://journal.frontiersin.org/Journal/10.3389/fnint.2011.00049/full |
| work_keys_str_mv | AT davejhayes identifyinganetworkofbrainregionsinvolvedinaversionrelatedprocessingacrossspeciestranslationalinvestigation AT georgenorthoff identifyinganetworkofbrainregionsinvolvedinaversionrelatedprocessingacrossspeciestranslationalinvestigation |