Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection
Background: Accurate and rapid assessment of allograft function is essential. Cystatin C has recently been proposed as an alternative marker of glomerular filtration rate (GFR). Its diagnostic value for the longitudinal assessment of graft function has not been addressed well. Objective: To study th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2015-10-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/358 |
| Summary: | Background: Accurate and rapid assessment of allograft function is essential. Cystatin C has recently been proposed as an alternative marker of glomerular filtration rate (GFR). Its diagnostic value for the longitudinal assessment of graft function has not been addressed well.
Objective: To study the validity of cystatin C as an early marker and predictor of acute transplant rejection in the first week post transplantation.
Subjects and Methods: Sixty six renal transplants recipients recruited. The study conducted in four renal transplantation centers in Baghdad for the period from September to December 2011. Serum creatinine and cystatin C concentrations measured 48 hours before transplantation and day 3 and 7 post transplantation.
Results: Serum Cystatin C observed to significantly increased at day 3 (p<0.0001) and still increased at day 7 in the rejection. On day 3 areas under the receiver operating characteristic (ROC) curves were 0.749 for creatinine and 0.909 for cystatin C. In patients with acute rejection, serum cystatin C level elevated earlier than serum creatinine.
Conclusion: Serum cystatin C seems to be a valuable marker of renal function in the first week post transplantation. |
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| ISSN: | 0041-9419 2410-8057 |