Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection
Background: Accurate and rapid assessment of allograft function is essential. Cystatin C has recently been proposed as an alternative marker of glomerular filtration rate (GFR). Its diagnostic value for the longitudinal assessment of graft function has not been addressed well. Objective: To study th...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2015-10-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/358 |
| _version_ | 1797331152814473216 |
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| author | Fadhil B. Shamkhi Ala Sh. Ali Hedef D. El-Yassin |
| author_facet | Fadhil B. Shamkhi Ala Sh. Ali Hedef D. El-Yassin |
| author_sort | Fadhil B. Shamkhi |
| collection | DOAJ |
| description | Background: Accurate and rapid assessment of allograft function is essential. Cystatin C has recently been proposed as an alternative marker of glomerular filtration rate (GFR). Its diagnostic value for the longitudinal assessment of graft function has not been addressed well.
Objective: To study the validity of cystatin C as an early marker and predictor of acute transplant rejection in the first week post transplantation.
Subjects and Methods: Sixty six renal transplants recipients recruited. The study conducted in four renal transplantation centers in Baghdad for the period from September to December 2011. Serum creatinine and cystatin C concentrations measured 48 hours before transplantation and day 3 and 7 post transplantation.
Results: Serum Cystatin C observed to significantly increased at day 3 (p<0.0001) and still increased at day 7 in the rejection. On day 3 areas under the receiver operating characteristic (ROC) curves were 0.749 for creatinine and 0.909 for cystatin C. In patients with acute rejection, serum cystatin C level elevated earlier than serum creatinine.
Conclusion: Serum cystatin C seems to be a valuable marker of renal function in the first week post transplantation. |
| first_indexed | 2024-03-08T07:30:23Z |
| format | Article |
| id | doaj.art-a856207cb9814ebdb73c3b1058b4ef6d |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T07:30:23Z |
| publishDate | 2015-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-a856207cb9814ebdb73c3b1058b4ef6d2024-02-02T20:41:07ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572015-10-0157310.32007/med.1936/jfacmedbagdad.v57i3.2Serum Cystatin C as a Predictor of Acute Kidney Transplant RejectionFadhil B. Shamkhi0Ala Sh. Ali1Hedef D. El-Yassin2Biochemistry. Nephrology and Renal Transplantation Center, The Medical City, Baghdad, Iraq.Biochemistry. Nephrology and Renal Transplantation Center, The Medical City, Baghdad, Iraq.Dept. of Biochemistry, College of Medicine, Baghdad University. Email: ala1975@gmail.com.Background: Accurate and rapid assessment of allograft function is essential. Cystatin C has recently been proposed as an alternative marker of glomerular filtration rate (GFR). Its diagnostic value for the longitudinal assessment of graft function has not been addressed well. Objective: To study the validity of cystatin C as an early marker and predictor of acute transplant rejection in the first week post transplantation. Subjects and Methods: Sixty six renal transplants recipients recruited. The study conducted in four renal transplantation centers in Baghdad for the period from September to December 2011. Serum creatinine and cystatin C concentrations measured 48 hours before transplantation and day 3 and 7 post transplantation. Results: Serum Cystatin C observed to significantly increased at day 3 (p<0.0001) and still increased at day 7 in the rejection. On day 3 areas under the receiver operating characteristic (ROC) curves were 0.749 for creatinine and 0.909 for cystatin C. In patients with acute rejection, serum cystatin C level elevated earlier than serum creatinine. Conclusion: Serum cystatin C seems to be a valuable marker of renal function in the first week post transplantation.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/358Cystatin C, Renal Transplantation, Acute Rejection. |
| spellingShingle | Fadhil B. Shamkhi Ala Sh. Ali Hedef D. El-Yassin Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection مجلة كلية الطب Cystatin C, Renal Transplantation, Acute Rejection. |
| title | Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection |
| title_full | Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection |
| title_fullStr | Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection |
| title_full_unstemmed | Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection |
| title_short | Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection |
| title_sort | serum cystatin c as a predictor of acute kidney transplant rejection |
| topic | Cystatin C, Renal Transplantation, Acute Rejection. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/358 |
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