Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells
The most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs.Previously we have revealed the effect of the transferring of the hormonal resistance fr...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2020-11-01
|
| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/291 |
| _version_ | 1797702312876048384 |
|---|---|
| author | D. V. Sorokin O. E. Andreeva E. I. Mikhaevich Yu. Yu. Shchegolev A. M. Scherbakov M. V. Gudkova M. A. Krasil’nikov |
| author_facet | D. V. Sorokin O. E. Andreeva E. I. Mikhaevich Yu. Yu. Shchegolev A. M. Scherbakov M. V. Gudkova M. A. Krasil’nikov |
| author_sort | D. V. Sorokin |
| collection | DOAJ |
| description | The most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs.Previously we have revealed the effect of the transferring of the hormonal resistance from the resistant to the sensitive cells under in vitro cell co-cultivation, and demonstrated exosomes involvement in this process. Here we have shown that the exosomes of the resistant cells caused the marked inhibition of the estrogen signaling in the recipient cells, and identified microRNAs – ERα suppressors that overexpressed in the resistant exosomes.Taken together, the results obtained demonstrate the important role of the estrogen signaling suppression in the exosome-induced transferring of the hormonal resistance, and revealed the involvement of the exosomal microRNA in the ERα down-regulation. |
| first_indexed | 2024-03-12T04:49:03Z |
| format | Article |
| id | doaj.art-a85876f2fe654ccc96ea9c4033542666 |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2024-03-12T04:49:03Z |
| publishDate | 2020-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-a85876f2fe654ccc96ea9c40335426662023-09-03T09:26:36ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872020-11-0173586210.17650/2313-805X-2020-7-3-58-62193Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cellsD. V. Sorokin0O. E. Andreeva1E. I. Mikhaevich2Yu. Yu. Shchegolev3A. M. Scherbakov4M. V. Gudkova5M. A. Krasil’nikov6НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииНИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииНИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииНИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииНИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииНИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииНИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииThe most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs.Previously we have revealed the effect of the transferring of the hormonal resistance from the resistant to the sensitive cells under in vitro cell co-cultivation, and demonstrated exosomes involvement in this process. Here we have shown that the exosomes of the resistant cells caused the marked inhibition of the estrogen signaling in the recipient cells, and identified microRNAs – ERα suppressors that overexpressed in the resistant exosomes.Taken together, the results obtained demonstrate the important role of the estrogen signaling suppression in the exosome-induced transferring of the hormonal resistance, and revealed the involvement of the exosomal microRNA in the ERα down-regulation.https://umo.abvpress.ru/jour/article/view/291экзосомыгормональная резистентностьмикрорнкрецептор эстрогенов erα |
| spellingShingle | D. V. Sorokin O. E. Andreeva E. I. Mikhaevich Yu. Yu. Shchegolev A. M. Scherbakov M. V. Gudkova M. A. Krasil’nikov Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells Успехи молекулярной онкологии экзосомы гормональная резистентность микрорнк рецептор эстрогенов erα |
| title | Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells |
| title_full | Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells |
| title_fullStr | Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells |
| title_full_unstemmed | Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells |
| title_short | Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells |
| title_sort | effect of the exosome mediated suppression of the estrogen signaling the role in the progression of the hormonal resistance of breast cancer cells |
| topic | экзосомы гормональная резистентность микрорнк рецептор эстрогенов erα |
| url | https://umo.abvpress.ru/jour/article/view/291 |
| work_keys_str_mv | AT dvsorokin effectoftheexosomemediatedsuppressionoftheestrogensignalingtheroleintheprogressionofthehormonalresistanceofbreastcancercells AT oeandreeva effectoftheexosomemediatedsuppressionoftheestrogensignalingtheroleintheprogressionofthehormonalresistanceofbreastcancercells AT eimikhaevich effectoftheexosomemediatedsuppressionoftheestrogensignalingtheroleintheprogressionofthehormonalresistanceofbreastcancercells AT yuyushchegolev effectoftheexosomemediatedsuppressionoftheestrogensignalingtheroleintheprogressionofthehormonalresistanceofbreastcancercells AT amscherbakov effectoftheexosomemediatedsuppressionoftheestrogensignalingtheroleintheprogressionofthehormonalresistanceofbreastcancercells AT mvgudkova effectoftheexosomemediatedsuppressionoftheestrogensignalingtheroleintheprogressionofthehormonalresistanceofbreastcancercells AT makrasilnikov effectoftheexosomemediatedsuppressionoftheestrogensignalingtheroleintheprogressionofthehormonalresistanceofbreastcancercells |