Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis
PURPOSE: Defining vascular calcification markers in patients on long-term hemodialysis (LTH) with type 2 diabetes mellitus (type 2 diabetes) and without type 2 diabetes. MATERIALS AND METHODS: The study was conducted in 82 patients with chronic kidney disease (CKD) (51 men, 31 women) on LTH, of whic...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2020-06-01
|
| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/10145 |
| _version_ | 1797255163604369408 |
|---|---|
| author | Tatyana V. Archakova Ludmila V. Nedosugova |
| author_facet | Tatyana V. Archakova Ludmila V. Nedosugova |
| author_sort | Tatyana V. Archakova |
| collection | DOAJ |
| description | PURPOSE: Defining vascular calcification markers in patients on long-term hemodialysis (LTH) with type 2 diabetes mellitus (type 2 diabetes) and without type 2 diabetes. MATERIALS AND METHODS: The study was conducted in 82 patients with chronic kidney disease (CKD) (51 men, 31 women) on LTH, of which 25 patients (10 men, 15 women) had type 2 diabetes and 57 people (33 men, 24 women) had no diabetes. All patients underwent evaluation of calcium-phosphate metabolism, control of intact PTH (iPTH), inorganic phosphorus, and total calcium. All patients were tested for the level of fibroblast growth factor-23 (FGF23) in blood serum using a multi-enzyme immunoassay kit, and the correlation between these parameters and the presence of vascular calcification was evaluated. RESULTS: A correlation was found between the severity of vascular calcification and the calcium-phosphate metabolism. In the group with type 2 diabetes, there is a correlation between the level of FGF23, iPTH, inorganic phosphorus and vascular calcification. There is also a correlation between the time on LTH and the increase in the level of FGF23 in patients with type 2 diabetes. CONCLUSION: We obtained data that can indicate a more pronounced change in the vascular wall in patients with type 2 diabetes on LTH in comparison with patients without diabetes mellitus on LTH, which allows to associate high cardiovascular mortality in patients with type 2 diabetes on LTH with accelerated development of vascular calcification. |
| first_indexed | 2024-03-08T15:19:26Z |
| format | Article |
| id | doaj.art-a8588a241a534d0c94d63d396f3f52eb |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:01:29Z |
| publishDate | 2020-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-a8588a241a534d0c94d63d396f3f52eb2024-03-20T11:48:03ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782020-06-0123212513110.14341/DM1014510661Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysisTatyana V. Archakova0Ludmila V. Nedosugova1I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityPURPOSE: Defining vascular calcification markers in patients on long-term hemodialysis (LTH) with type 2 diabetes mellitus (type 2 diabetes) and without type 2 diabetes. MATERIALS AND METHODS: The study was conducted in 82 patients with chronic kidney disease (CKD) (51 men, 31 women) on LTH, of which 25 patients (10 men, 15 women) had type 2 diabetes and 57 people (33 men, 24 women) had no diabetes. All patients underwent evaluation of calcium-phosphate metabolism, control of intact PTH (iPTH), inorganic phosphorus, and total calcium. All patients were tested for the level of fibroblast growth factor-23 (FGF23) in blood serum using a multi-enzyme immunoassay kit, and the correlation between these parameters and the presence of vascular calcification was evaluated. RESULTS: A correlation was found between the severity of vascular calcification and the calcium-phosphate metabolism. In the group with type 2 diabetes, there is a correlation between the level of FGF23, iPTH, inorganic phosphorus and vascular calcification. There is also a correlation between the time on LTH and the increase in the level of FGF23 in patients with type 2 diabetes. CONCLUSION: We obtained data that can indicate a more pronounced change in the vascular wall in patients with type 2 diabetes on LTH in comparison with patients without diabetes mellitus on LTH, which allows to associate high cardiovascular mortality in patients with type 2 diabetes on LTH with accelerated development of vascular calcification.https://www.dia-endojournals.ru/jour/article/view/10145type 2 diabetes mellitusvascular calcificationlong-term hemodialysisfibroblast growth factor 23 |
| spellingShingle | Tatyana V. Archakova Ludmila V. Nedosugova Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis Сахарный диабет type 2 diabetes mellitus vascular calcification long-term hemodialysis fibroblast growth factor 23 |
| title | Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis |
| title_full | Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis |
| title_fullStr | Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis |
| title_full_unstemmed | Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis |
| title_short | Factors of vascular calcification in patients with type 2 diabetes mellitus on long-term dialysis |
| title_sort | factors of vascular calcification in patients with type 2 diabetes mellitus on long term dialysis |
| topic | type 2 diabetes mellitus vascular calcification long-term hemodialysis fibroblast growth factor 23 |
| url | https://www.dia-endojournals.ru/jour/article/view/10145 |
| work_keys_str_mv | AT tatyanavarchakova factorsofvascularcalcificationinpatientswithtype2diabetesmellitusonlongtermdialysis AT ludmilavnedosugova factorsofvascularcalcificationinpatientswithtype2diabetesmellitusonlongtermdialysis |