Multidimensional Genetic Analysis of Repeated Seizures in the Hybrid Mouse Diversity Panel Reveals a Novel Epileptogenesis Susceptibility Locus

Multidimensional Genetic Analysis of Repeated Seizures in the Hybrid Mouse Diversity Panel Reveals a Novel Epileptogenesis Susceptibility Locus

Epilepsy has many causes and comorbidities affecting as many as 4% of people in their lifetime. Both idiopathic and symptomatic epilepsies are highly heritable, but genetic factors are difficult to characterize among humans due to complex disease etiologies. Rodent genetic studies have been critical...

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Bibliographic Details
Main Authors: Russell J. Ferland, Jason Smith, Dominick Papandrea, Jessica Gracias, Leah Hains, Sridhar B. Kadiyala, Brittany O’Brien, Eun Yong Kang, Barbara S. Beyer, Bruce J. Herron
Format: Article
Language:English
Published: Oxford University Press 2017-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
genetics
epilepsy
preclinical model
neuronal plasticity
complex traits
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.042234

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