Eosinophilic gastrointestinal diseases – Pathogenesis, diagnosis, and treatment
Eosinophilic gastrointestinal diseases (EGIDs) are divided into eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), depending on the involved gastrointestinal tract, though both are considered to be chronic Th2-type allergic diseases caused by food or environmental allergens. In d...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Allergology International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893019300358 |
| _version_ | 1811263057783947264 |
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| author | Yoshikazu Kinoshita Sachiko Oouchi Takashi Fujisawa |
| author_facet | Yoshikazu Kinoshita Sachiko Oouchi Takashi Fujisawa |
| author_sort | Yoshikazu Kinoshita |
| collection | DOAJ |
| description | Eosinophilic gastrointestinal diseases (EGIDs) are divided into eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), depending on the involved gastrointestinal tract, though both are considered to be chronic Th2-type allergic diseases caused by food or environmental allergens. In development of EoE, refluxed gastric acid may also have an important role. For diagnosis of EGIDs, the presence of symptoms possibly originating from the involved gastrointestinal tract and dense eosinophil infiltration are important factors. Imaging studies, including endoscopy and computed tomography, along with histopathological examinations of biopsy specimens are useful for diagnosis, whereas laboratory testing of blood, urine, and stool samples has limited value. Three useful options for treating EoE patients are acid inhibitors, swallowed topical corticosteroids, and an elimination diet, while systemic administration of glucocorticoids is the standard treatment of EGE, though information is limited. Since the prevalence of EGIDs is increasing in Western countries as well as Japan, development of effective treatments based on sufficient evidence is becoming an urgent need. Keywords: Allergy, Esophagus, Gastric acid, Lymphocyte, Small intestine |
| first_indexed | 2024-04-12T19:38:01Z |
| format | Article |
| id | doaj.art-a85afdd149304fe09cccf4675da44584 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-12T19:38:01Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-a85afdd149304fe09cccf4675da445842022-12-22T03:19:10ZengElsevierAllergology International1323-89302019-10-01684420429Eosinophilic gastrointestinal diseases – Pathogenesis, diagnosis, and treatmentYoshikazu Kinoshita0Sachiko Oouchi1Takashi Fujisawa2Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan; Department of Medicine, Steel Memorial Hirohata Hospital, Himeji, Japan; Corresponding author. Department of Medicine, Steel Memorial Hirohata Hospital, 3-1, Yumesaki-cho, Hirohata-ku, Himeji, Hyogo 671-1122, Japan.Department of Medicine, Steel Memorial Hirohata Hospital, Himeji, JapanDepartment of Medicine, Steel Memorial Hirohata Hospital, Himeji, JapanEosinophilic gastrointestinal diseases (EGIDs) are divided into eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), depending on the involved gastrointestinal tract, though both are considered to be chronic Th2-type allergic diseases caused by food or environmental allergens. In development of EoE, refluxed gastric acid may also have an important role. For diagnosis of EGIDs, the presence of symptoms possibly originating from the involved gastrointestinal tract and dense eosinophil infiltration are important factors. Imaging studies, including endoscopy and computed tomography, along with histopathological examinations of biopsy specimens are useful for diagnosis, whereas laboratory testing of blood, urine, and stool samples has limited value. Three useful options for treating EoE patients are acid inhibitors, swallowed topical corticosteroids, and an elimination diet, while systemic administration of glucocorticoids is the standard treatment of EGE, though information is limited. Since the prevalence of EGIDs is increasing in Western countries as well as Japan, development of effective treatments based on sufficient evidence is becoming an urgent need. Keywords: Allergy, Esophagus, Gastric acid, Lymphocyte, Small intestinehttp://www.sciencedirect.com/science/article/pii/S1323893019300358 |
| spellingShingle | Yoshikazu Kinoshita Sachiko Oouchi Takashi Fujisawa Eosinophilic gastrointestinal diseases – Pathogenesis, diagnosis, and treatment Allergology International |
| title | Eosinophilic gastrointestinal diseases – Pathogenesis, diagnosis, and treatment |
| title_full | Eosinophilic gastrointestinal diseases – Pathogenesis, diagnosis, and treatment |
| title_fullStr | Eosinophilic gastrointestinal diseases – Pathogenesis, diagnosis, and treatment |
| title_full_unstemmed | Eosinophilic gastrointestinal diseases – Pathogenesis, diagnosis, and treatment |
| title_short | Eosinophilic gastrointestinal diseases – Pathogenesis, diagnosis, and treatment |
| title_sort | eosinophilic gastrointestinal diseases pathogenesis diagnosis and treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1323893019300358 |
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