Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective
Mobility is an intrinsic feature of the animal kingdom that stimulates evolutionary processes and determines the biological success of animals. Skeletal muscle is the primary driver of voluntary movements. Besides, skeletal muscles have an immense impact on regulating glucose, amino acid, and lipid...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/4/644 |
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| author | Bushra Khan Luis Vincens Gand Mamta Amrute-Nayak Arnab Nayak |
| author_facet | Bushra Khan Luis Vincens Gand Mamta Amrute-Nayak Arnab Nayak |
| author_sort | Bushra Khan |
| collection | DOAJ |
| description | Mobility is an intrinsic feature of the animal kingdom that stimulates evolutionary processes and determines the biological success of animals. Skeletal muscle is the primary driver of voluntary movements. Besides, skeletal muscles have an immense impact on regulating glucose, amino acid, and lipid homeostasis. Muscle atrophy/wasting conditions are accompanied by a drastic effect on muscle function and disrupt steady-state muscle physiology. Cachexia is a complex multifactorial muscle wasting syndrome characterized by extreme loss of skeletal muscle mass, resulting in a dramatic decrease in life quality and reported mortality in more than 30% of patients with advanced cancers. The lack of directed treatments to prevent or relieve muscle loss indicates our inadequate knowledge of molecular mechanisms involved in muscle cell organization and the molecular etiology of cancer-induced cachexia (CIC). This review highlights the latest knowledge of regulatory mechanisms involved in maintaining muscle function and their deregulation in wasting syndromes, particularly in cachexia. Recently, protein posttranslational modification by the small ubiquitin-like modifier (SUMO) has emerged as a key regulatory mechanism of protein function with implications for different aspects of cell physiology and diseases. We also review an atypical association of SUMO-mediated pathways in this context and deliberate on potential treatment strategies to alleviate muscle atrophy. |
| first_indexed | 2024-03-11T09:01:08Z |
| format | Article |
| id | doaj.art-a85b1e27d73447a1a075020377857991 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:01:08Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a85b1e27d73447a1a0750203778579912023-11-16T19:45:14ZengMDPI AGCells2073-44092023-02-0112464410.3390/cells12040644Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO PerspectiveBushra Khan0Luis Vincens Gand1Mamta Amrute-Nayak2Arnab Nayak3Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyInstitute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyInstitute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyInstitute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyMobility is an intrinsic feature of the animal kingdom that stimulates evolutionary processes and determines the biological success of animals. Skeletal muscle is the primary driver of voluntary movements. Besides, skeletal muscles have an immense impact on regulating glucose, amino acid, and lipid homeostasis. Muscle atrophy/wasting conditions are accompanied by a drastic effect on muscle function and disrupt steady-state muscle physiology. Cachexia is a complex multifactorial muscle wasting syndrome characterized by extreme loss of skeletal muscle mass, resulting in a dramatic decrease in life quality and reported mortality in more than 30% of patients with advanced cancers. The lack of directed treatments to prevent or relieve muscle loss indicates our inadequate knowledge of molecular mechanisms involved in muscle cell organization and the molecular etiology of cancer-induced cachexia (CIC). This review highlights the latest knowledge of regulatory mechanisms involved in maintaining muscle function and their deregulation in wasting syndromes, particularly in cachexia. Recently, protein posttranslational modification by the small ubiquitin-like modifier (SUMO) has emerged as a key regulatory mechanism of protein function with implications for different aspects of cell physiology and diseases. We also review an atypical association of SUMO-mediated pathways in this context and deliberate on potential treatment strategies to alleviate muscle atrophy.https://www.mdpi.com/2073-4409/12/4/644sarcomeremuscle atrophycachexiamuscle metabolismchromatin signalingubiquitination |
| spellingShingle | Bushra Khan Luis Vincens Gand Mamta Amrute-Nayak Arnab Nayak Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective Cells sarcomere muscle atrophy cachexia muscle metabolism chromatin signaling ubiquitination |
| title | Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective |
| title_full | Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective |
| title_fullStr | Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective |
| title_full_unstemmed | Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective |
| title_short | Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective |
| title_sort | emerging mechanisms of skeletal muscle homeostasis and cachexia the sumo perspective |
| topic | sarcomere muscle atrophy cachexia muscle metabolism chromatin signaling ubiquitination |
| url | https://www.mdpi.com/2073-4409/12/4/644 |
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