Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale”
Oral tongue squamous-cell carcinoma (OTSCC) is the most prevalent malignancy in the head and neck region. Lymphatic spread, particularly to cervical lymph nodes, significantly impacts 5-year survival rates, emphasizing the criticality of precise staging. Metastatic cervical lymph nodes can decrease...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/6/1153 |
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| author | Franco Ionna Ettore Pavone Corrado Aversa Francesco Maffia Raffaele Spinelli Emanuele Carraturo Giovanni Salzano Fabio Maglitto Marco Sarcinella Roberta Fusco Vincenza Granata Secondo Lastoria Francesco Del Prato Maria Grazia Maglione |
| author_facet | Franco Ionna Ettore Pavone Corrado Aversa Francesco Maffia Raffaele Spinelli Emanuele Carraturo Giovanni Salzano Fabio Maglitto Marco Sarcinella Roberta Fusco Vincenza Granata Secondo Lastoria Francesco Del Prato Maria Grazia Maglione |
| author_sort | Franco Ionna |
| collection | DOAJ |
| description | Oral tongue squamous-cell carcinoma (OTSCC) is the most prevalent malignancy in the head and neck region. Lymphatic spread, particularly to cervical lymph nodes, significantly impacts 5-year survival rates, emphasizing the criticality of precise staging. Metastatic cervical lymph nodes can decrease survival rates by 50%. Yet, elective neck dissection (END) in T1–2 cN0 patients proves to be an overtreatment in around 80% of cases. To address this, sentinel lymph node biopsy (SLNB) was introduced, aiming to minimize postoperative morbidity. This study, conducted at the ENT and Maxillofacial Surgery department of the Istituto Nazionale Tumori in Naples, explores SLNB’s efficacy in early-stage oral tongue squamous-cell carcinoma (OTSCC). From January 2020 to January 2022, 122 T1/T2 cN0 HNSCC patients were enrolled. Radioactive tracers and lymphoscintigraphy identified sentinel lymph nodes, aided by a gamma probe during surgery. Results revealed 24.6% SLN biopsy positivity, with 169 SLNs resected and a 21.9% positivity ratio. The study suggests SLNB’s reliability for T1-2 cN0 OTSCC patient staging and early micrometastasis detection. |
| first_indexed | 2024-04-24T18:28:13Z |
| format | Article |
| id | doaj.art-a85b462e86bc49b69a22990a480e80ab |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-04-24T18:28:13Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a85b462e86bc49b69a22990a480e80ab2024-03-27T13:29:58ZengMDPI AGCancers2072-66942024-03-01166115310.3390/cancers16061153Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale”Franco Ionna0Ettore Pavone1Corrado Aversa2Francesco Maffia3Raffaele Spinelli4Emanuele Carraturo5Giovanni Salzano6Fabio Maglitto7Marco Sarcinella8Roberta Fusco9Vincenza Granata10Secondo Lastoria11Francesco Del Prato12Maria Grazia Maglione13Istituto Nazionale Tumori—IRCCS—Fondazione “G.Pascale”, 80131 Naples, ItalyIstituto Nazionale Tumori—IRCCS—Fondazione “G.Pascale”, 80131 Naples, ItalyIstituto Nazionale Tumori—IRCCS—Fondazione “G.Pascale”, 80131 Naples, ItalyMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, ItalyMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, ItalyMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, ItalyMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, ItalyMaxillofacial Surgery Operative Unit, Department of Interdisciplinary Medicine, Aldo Moro University of Bari, 70120 Bari, ItalyMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, ItalyIstituto Nazionale Tumori—IRCCS—Fondazione “G.Pascale”, 80131 Naples, ItalyIstituto Nazionale Tumori—IRCCS—Fondazione “G.Pascale”, 80131 Naples, ItalyIstituto Nazionale Tumori—IRCCS—Fondazione “G.Pascale”, 80131 Naples, ItalyIstituto Nazionale Tumori—IRCCS—Fondazione “G.Pascale”, 80131 Naples, ItalyIstituto Nazionale Tumori—IRCCS—Fondazione “G.Pascale”, 80131 Naples, ItalyOral tongue squamous-cell carcinoma (OTSCC) is the most prevalent malignancy in the head and neck region. Lymphatic spread, particularly to cervical lymph nodes, significantly impacts 5-year survival rates, emphasizing the criticality of precise staging. Metastatic cervical lymph nodes can decrease survival rates by 50%. Yet, elective neck dissection (END) in T1–2 cN0 patients proves to be an overtreatment in around 80% of cases. To address this, sentinel lymph node biopsy (SLNB) was introduced, aiming to minimize postoperative morbidity. This study, conducted at the ENT and Maxillofacial Surgery department of the Istituto Nazionale Tumori in Naples, explores SLNB’s efficacy in early-stage oral tongue squamous-cell carcinoma (OTSCC). From January 2020 to January 2022, 122 T1/T2 cN0 HNSCC patients were enrolled. Radioactive tracers and lymphoscintigraphy identified sentinel lymph nodes, aided by a gamma probe during surgery. Results revealed 24.6% SLN biopsy positivity, with 169 SLNs resected and a 21.9% positivity ratio. The study suggests SLNB’s reliability for T1-2 cN0 OTSCC patient staging and early micrometastasis detection.https://www.mdpi.com/2072-6694/16/6/1153head and neck canceroral tongue cancersentinel lymph node biopsyneck metastasisneck dissectionoccult metastasis |
| spellingShingle | Franco Ionna Ettore Pavone Corrado Aversa Francesco Maffia Raffaele Spinelli Emanuele Carraturo Giovanni Salzano Fabio Maglitto Marco Sarcinella Roberta Fusco Vincenza Granata Secondo Lastoria Francesco Del Prato Maria Grazia Maglione Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale” Cancers head and neck cancer oral tongue cancer sentinel lymph node biopsy neck metastasis neck dissection occult metastasis |
| title | Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale” |
| title_full | Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale” |
| title_fullStr | Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale” |
| title_full_unstemmed | Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale” |
| title_short | Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale” |
| title_sort | sentinel lymph node biopsy slnb for early stage head and neck squamous cell carcinoma of the tongue twenty years of experience at i n t g pascale |
| topic | head and neck cancer oral tongue cancer sentinel lymph node biopsy neck metastasis neck dissection occult metastasis |
| url | https://www.mdpi.com/2072-6694/16/6/1153 |
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