Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour

The authors reveal a mechanism for regulation of behaviour during approach avoidance conflicts that relies on two specialized, parallel circuits that allow bidirectional hippocampal control of the prefrontal cortex.

Bibliographic Details
Main Authors: Candela Sánchez-Bellot, Rawan AlSubaie, Karyna Mishchanchuk, Ryan W. S. Wee, Andrew F. MacAskill
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-27977-7
_version_ 1818333020770271232
author Candela Sánchez-Bellot
Rawan AlSubaie
Karyna Mishchanchuk
Ryan W. S. Wee
Andrew F. MacAskill
author_facet Candela Sánchez-Bellot
Rawan AlSubaie
Karyna Mishchanchuk
Ryan W. S. Wee
Andrew F. MacAskill
author_sort Candela Sánchez-Bellot
collection DOAJ
description The authors reveal a mechanism for regulation of behaviour during approach avoidance conflicts that relies on two specialized, parallel circuits that allow bidirectional hippocampal control of the prefrontal cortex.
first_indexed 2024-12-13T13:45:00Z
format Article
id doaj.art-a85b52c8e6a847ae804207b49d3e7d6f
institution Directory Open Access Journal
issn 2041-1723
language English
last_indexed 2024-12-13T13:45:00Z
publishDate 2022-01-01
publisher Nature Portfolio
record_format Article
series Nature Communications
spelling doaj.art-a85b52c8e6a847ae804207b49d3e7d6f2022-12-21T23:43:29ZengNature PortfolioNature Communications2041-17232022-01-0113111710.1038/s41467-022-27977-7Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviourCandela Sánchez-Bellot0Rawan AlSubaie1Karyna Mishchanchuk2Ryan W. S. Wee3Andrew F. MacAskill4Department of Neuroscience, Physiology and Pharmacology, University College London, Gower StDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower StDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower StDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower StDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower StThe authors reveal a mechanism for regulation of behaviour during approach avoidance conflicts that relies on two specialized, parallel circuits that allow bidirectional hippocampal control of the prefrontal cortex.https://doi.org/10.1038/s41467-022-27977-7
spellingShingle Candela Sánchez-Bellot
Rawan AlSubaie
Karyna Mishchanchuk
Ryan W. S. Wee
Andrew F. MacAskill
Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour
Nature Communications
title Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour
title_full Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour
title_fullStr Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour
title_full_unstemmed Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour
title_short Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour
title_sort two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour
url https://doi.org/10.1038/s41467-022-27977-7
work_keys_str_mv AT candelasanchezbellot twoopposinghippocampustoprefrontalcortexpathwaysforthecontrolofapproachandavoidancebehaviour
AT rawanalsubaie twoopposinghippocampustoprefrontalcortexpathwaysforthecontrolofapproachandavoidancebehaviour
AT karynamishchanchuk twoopposinghippocampustoprefrontalcortexpathwaysforthecontrolofapproachandavoidancebehaviour
AT ryanwswee twoopposinghippocampustoprefrontalcortexpathwaysforthecontrolofapproachandavoidancebehaviour
AT andrewfmacaskill twoopposinghippocampustoprefrontalcortexpathwaysforthecontrolofapproachandavoidancebehaviour