Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors
Abstract Background Recent advance in tissue characterization with parametric mapping imaging has the potential to be a novel biomarker for histopathologic correlation with thymic epithelial tumors (TETs). The purpose of our study is to evaluate MRI T1 mapping with the calculation of extracellular v...
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BMC
2020-10-01
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| Series: | Cancer Imaging |
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| Online Access: | http://link.springer.com/article/10.1186/s40644-020-00349-4 |
| _version_ | 1818602876544483328 |
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| author | Chao-Chun Chang Chia-Ying Lin Chang-Yao Chu Yi-Cheng Hsiung Ming-Tsung Chuang Yau-Lin Tseng Yi-Ting Yen |
| author_facet | Chao-Chun Chang Chia-Ying Lin Chang-Yao Chu Yi-Cheng Hsiung Ming-Tsung Chuang Yau-Lin Tseng Yi-Ting Yen |
| author_sort | Chao-Chun Chang |
| collection | DOAJ |
| description | Abstract Background Recent advance in tissue characterization with parametric mapping imaging has the potential to be a novel biomarker for histopathologic correlation with thymic epithelial tumors (TETs). The purpose of our study is to evaluate MRI T1 mapping with the calculation of extracellular volume (ECV) fraction for histologic correlation with thymic epithelial tumor based on lymphocyte abundance. Methods A retrospective study including 31 consecutive patients (14 men and 17 women, median age, 56 years; interquartile range, 12 years) with TETs was performed. The T1 values and ECV were assessed by using quantitative MRI mapping techniques. Mann-Whitney U test, Kruskal-Wallis H test, and receiver operating characteristic curve analyses were used to assess discrimination between different types of TETs based on lymphocyte abundance. Results Extracellular volume was significantly higher in TETs with sparse lymphocyte, including type A, type B3, and thymic carcinoma, compared with those with abundant lymphocyte, including type B1, B2, and AB thymomas (42.5% vs 26.9%, respectively; p < 0.001). Extracellular volume was significantly higher in thymic carcinoma compared with low grade and high grade thymomas (48.6% vs 31.1% vs 27.6%, respectively; p = 0.002). Conclusions T1 mapping with the calculation of extracellular volume (ECV) fraction correlate with the WHO histologic classification of thymic epithelial tumor based on lymphocyte abundance. |
| first_indexed | 2024-12-16T13:14:15Z |
| format | Article |
| id | doaj.art-a85b60ec846c4e7e95835fd308c9db02 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-12-16T13:14:15Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-a85b60ec846c4e7e95835fd308c9db022022-12-21T22:30:31ZengBMCCancer Imaging1470-73302020-10-0120111110.1186/s40644-020-00349-4Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumorsChao-Chun Chang0Chia-Ying Lin1Chang-Yao Chu2Yi-Cheng Hsiung3Ming-Tsung Chuang4Yau-Lin Tseng5Yi-Ting Yen6Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityDepartment of Medical Imaging, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityDepartment of Pathology, National Cheng Kung University HospitalDepartment of Medical Imaging, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityDepartment of Medical Imaging, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityDivision of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityDivision of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityAbstract Background Recent advance in tissue characterization with parametric mapping imaging has the potential to be a novel biomarker for histopathologic correlation with thymic epithelial tumors (TETs). The purpose of our study is to evaluate MRI T1 mapping with the calculation of extracellular volume (ECV) fraction for histologic correlation with thymic epithelial tumor based on lymphocyte abundance. Methods A retrospective study including 31 consecutive patients (14 men and 17 women, median age, 56 years; interquartile range, 12 years) with TETs was performed. The T1 values and ECV were assessed by using quantitative MRI mapping techniques. Mann-Whitney U test, Kruskal-Wallis H test, and receiver operating characteristic curve analyses were used to assess discrimination between different types of TETs based on lymphocyte abundance. Results Extracellular volume was significantly higher in TETs with sparse lymphocyte, including type A, type B3, and thymic carcinoma, compared with those with abundant lymphocyte, including type B1, B2, and AB thymomas (42.5% vs 26.9%, respectively; p < 0.001). Extracellular volume was significantly higher in thymic carcinoma compared with low grade and high grade thymomas (48.6% vs 31.1% vs 27.6%, respectively; p = 0.002). Conclusions T1 mapping with the calculation of extracellular volume (ECV) fraction correlate with the WHO histologic classification of thymic epithelial tumor based on lymphocyte abundance.http://link.springer.com/article/10.1186/s40644-020-00349-4Extracellular spaceMagnetic resonance imagingThymic epithelial tumor (TET)World Health Organization (WHO) |
| spellingShingle | Chao-Chun Chang Chia-Ying Lin Chang-Yao Chu Yi-Cheng Hsiung Ming-Tsung Chuang Yau-Lin Tseng Yi-Ting Yen Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors Cancer Imaging Extracellular space Magnetic resonance imaging Thymic epithelial tumor (TET) World Health Organization (WHO) |
| title | Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors |
| title_full | Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors |
| title_fullStr | Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors |
| title_full_unstemmed | Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors |
| title_short | Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors |
| title_sort | extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors |
| topic | Extracellular space Magnetic resonance imaging Thymic epithelial tumor (TET) World Health Organization (WHO) |
| url | http://link.springer.com/article/10.1186/s40644-020-00349-4 |
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