Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review
Knowledge of other Coronaviruses has contributed to the development of a vaccine for the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). As soon as the genetic sequence of SARS-CoV-2 was released, intense global activity around different vaccine platform technologies started. Among th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-07-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/8931 |
| _version_ | 1797768501166866432 |
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| author | Andréia Michelle Alves Cunha de Alcântar Ivan de Alcântara Barbosa Barros Luiz Paulo de Souza Prazeres Ivan Barbosa Barros Maria De Mascena Diniz Paulo Souza Roberto Eleutério de Souza |
| author_facet | Andréia Michelle Alves Cunha de Alcântar Ivan de Alcântara Barbosa Barros Luiz Paulo de Souza Prazeres Ivan Barbosa Barros Maria De Mascena Diniz Paulo Souza Roberto Eleutério de Souza |
| author_sort | Andréia Michelle Alves Cunha de Alcântar |
| collection | DOAJ |
| description |
Knowledge of other Coronaviruses has contributed to the development of a vaccine for the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). As soon as the genetic sequence of SARS-CoV-2 was released, intense global activity around different vaccine platform technologies started. Among these platforms, the viral vectored chimpanzee adenovirus Oxford1 (ChAdOx1)-previously studied for various indications, including for the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) vaccine, and currently is adapted for the ChAdOx1 nCoV-19 (novel Coronavirus-19). Therefore, this systematic review aimed to investigate the potential of the ChAdOx1 platform for the development of a vaccine for SARS-CoV and MERS-CoV, the Lethal Human-Coronaviruses (Lh-CoVs). For this purpose, a highly sensitive literary search was conducted through electronic databases that reached 1,445 related articles, of which, eight articles were elected according to previous eligibility criteria. The gathering of the articles demonstrated that the previous approaches, referring to the ChAdox1 platform, have contributed to the development of vaccines against Lh-CoVs and, that thus far, ChAdOx1 (nCoV-19 and MERS) vaccines are safe and immunogenic. However, it is important to emphasize that further studies are needed to ensure the effectiveness of vaccines in humans.
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| first_indexed | 2024-03-12T20:54:29Z |
| format | Article |
| id | doaj.art-a85bc57751f14ef79cc35fb2c2801479 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-03-12T20:54:29Z |
| publishDate | 2023-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-a85bc57751f14ef79cc35fb2c28014792023-07-31T20:43:55ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942023-07-0161410.18502/acta.v61i4.13169Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic ReviewAndréia Michelle Alves Cunha de Alcântar0Ivan de Alcântara Barbosa Barros1Luiz Paulo de Souza Prazeres2Ivan Barbosa Barros3Maria De Mascena Diniz4Paulo Souza Roberto Eleutério de Souza5Department of Animal Bioscience, Federal Rural University of Pernambuco, Pernambuco, BrazilDepartment of Computer Engineering, Institute of Education and Research, São Paulo, BrazilDepartment of Medicine, Federal University of Alagoas, Alagoas, BrazilDepartment of Mathematics, Federal University of Pernambuco, Pernambuco, Brazilhttps://orcid.org/0000-0001-5893-455XDepartment of Animal Bioscience, Federal Rural University of Pernambuco, Pernambuco, Brazil Knowledge of other Coronaviruses has contributed to the development of a vaccine for the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). As soon as the genetic sequence of SARS-CoV-2 was released, intense global activity around different vaccine platform technologies started. Among these platforms, the viral vectored chimpanzee adenovirus Oxford1 (ChAdOx1)-previously studied for various indications, including for the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) vaccine, and currently is adapted for the ChAdOx1 nCoV-19 (novel Coronavirus-19). Therefore, this systematic review aimed to investigate the potential of the ChAdOx1 platform for the development of a vaccine for SARS-CoV and MERS-CoV, the Lethal Human-Coronaviruses (Lh-CoVs). For this purpose, a highly sensitive literary search was conducted through electronic databases that reached 1,445 related articles, of which, eight articles were elected according to previous eligibility criteria. The gathering of the articles demonstrated that the previous approaches, referring to the ChAdox1 platform, have contributed to the development of vaccines against Lh-CoVs and, that thus far, ChAdOx1 (nCoV-19 and MERS) vaccines are safe and immunogenic. However, it is important to emphasize that further studies are needed to ensure the effectiveness of vaccines in humans. https://acta.tums.ac.ir/index.php/acta/article/view/8931Chimpanzee adenovirus oxford 1 (ChAdOx1)VaccineCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV2)Middle east respiratory syndrome (MERS-CoV)Coronavirus disease 2019 (COVID-19) |
| spellingShingle | Andréia Michelle Alves Cunha de Alcântar Ivan de Alcântara Barbosa Barros Luiz Paulo de Souza Prazeres Ivan Barbosa Barros Maria De Mascena Diniz Paulo Souza Roberto Eleutério de Souza Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review Acta Medica Iranica Chimpanzee adenovirus oxford 1 (ChAdOx1) Vaccine Coronavirus Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) Middle east respiratory syndrome (MERS-CoV) Coronavirus disease 2019 (COVID-19) |
| title | Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review |
| title_full | Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review |
| title_fullStr | Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review |
| title_full_unstemmed | Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review |
| title_short | Is the ChAdOx1 Vaccine Safe and Immunogenic as Prophylactic Measure Against the Lethal Human-Coronaviruses? A Systematic Review |
| title_sort | is the chadox1 vaccine safe and immunogenic as prophylactic measure against the lethal human coronaviruses a systematic review |
| topic | Chimpanzee adenovirus oxford 1 (ChAdOx1) Vaccine Coronavirus Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) Middle east respiratory syndrome (MERS-CoV) Coronavirus disease 2019 (COVID-19) |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/8931 |
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