Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β) Cytokines in Cutaneous Leishmaniasis Patients in Iraq
This study aimed to study the effective antimonial therapy on circulating levels proinflammatory cytokines, and their effect on susceptibility to cutaneous leishmaniasis (CL) infection in the Iraqi population. Fifty CssL patients were treated with pentavalent antimonial salts (pentostam) for 7 weeks...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2019-12-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v11i4.p340-346 |
| _version_ | 1797673392440082432 |
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| author | Hasan Raheem Khudhur Ahmed Abbas Hasan Rawaa Adday Ali |
| author_facet | Hasan Raheem Khudhur Ahmed Abbas Hasan Rawaa Adday Ali |
| author_sort | Hasan Raheem Khudhur |
| collection | DOAJ |
| description | This study aimed to study the effective antimonial therapy on circulating levels proinflammatory cytokines, and their effect on susceptibility to cutaneous leishmaniasis (CL) infection in the Iraqi population. Fifty CssL patients were treated with pentavalent antimonial salts (pentostam) for 7 weeks. Leishmania species were identified by Nested-Polymerase chain reaction method, and in all the cases the strains corresponded to Leishmania major. Circulating plasma levels of the proinflammatory cytokines interleukin-1 and tumor necrosis factor-alpha were determined for CL patients and healthy subjects before and during 7 weeks after the treatment were started. Concentrations were detected by enzyme-linked immunosorbent assay technique using a quantitative sandwich enzyme immunoassay technique. Proinflammatory cytokines significantly increased after 7 days postinfection compared to levels in the pretreatment patients. It was clearly recorded in the present study that the level of interleukin-1 and tumor necrosis factor-alpha in the serum of CL patients was responsively increasing with the antimonial therapy dose. |
| first_indexed | 2024-03-11T21:43:49Z |
| format | Article |
| id | doaj.art-a85d96d48897488e86402be0c6063ff2 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:43:49Z |
| publishDate | 2019-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-a85d96d48897488e86402be0c6063ff22023-09-26T11:03:45ZengTsinghua University PressNano Biomedicine and Engineering2150-55782019-12-0111434034610.5101/nbe.v11i4.p340-346Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β) Cytokines in Cutaneous Leishmaniasis Patients in IraqHasan Raheem Khudhur0Ahmed Abbas Hasan1Rawaa Adday Ali2Ministry of Education, IraqCollege of Health and Medical Techniques, Kufa, Al-Furat Al-Awsat Technical University, 31003 Al-Kufa, IraqAL-Qasim Green University, College of Veterinary Medicine, Microbiology Department, IraqThis study aimed to study the effective antimonial therapy on circulating levels proinflammatory cytokines, and their effect on susceptibility to cutaneous leishmaniasis (CL) infection in the Iraqi population. Fifty CssL patients were treated with pentavalent antimonial salts (pentostam) for 7 weeks. Leishmania species were identified by Nested-Polymerase chain reaction method, and in all the cases the strains corresponded to Leishmania major. Circulating plasma levels of the proinflammatory cytokines interleukin-1 and tumor necrosis factor-alpha were determined for CL patients and healthy subjects before and during 7 weeks after the treatment were started. Concentrations were detected by enzyme-linked immunosorbent assay technique using a quantitative sandwich enzyme immunoassay technique. Proinflammatory cytokines significantly increased after 7 days postinfection compared to levels in the pretreatment patients. It was clearly recorded in the present study that the level of interleukin-1 and tumor necrosis factor-alpha in the serum of CL patients was responsively increasing with the antimonial therapy dose.https://www.sciopen.com/article/10.5101/nbe.v11i4.p340-346cutaneous leishmaniasisantimonial therapytnf-α and il-1βiraq |
| spellingShingle | Hasan Raheem Khudhur Ahmed Abbas Hasan Rawaa Adday Ali Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β) Cytokines in Cutaneous Leishmaniasis Patients in Iraq Nano Biomedicine and Engineering cutaneous leishmaniasis antimonial therapy tnf-α and il-1β iraq |
| title | Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β) Cytokines in Cutaneous Leishmaniasis Patients in Iraq |
| title_full | Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β) Cytokines in Cutaneous Leishmaniasis Patients in Iraq |
| title_fullStr | Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β) Cytokines in Cutaneous Leishmaniasis Patients in Iraq |
| title_full_unstemmed | Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β) Cytokines in Cutaneous Leishmaniasis Patients in Iraq |
| title_short | Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β) Cytokines in Cutaneous Leishmaniasis Patients in Iraq |
| title_sort | effect of antimonial therapy on levels of tnf α and il 1β cytokines in cutaneous leishmaniasis patients in iraq |
| topic | cutaneous leishmaniasis antimonial therapy tnf-α and il-1β iraq |
| url | https://www.sciopen.com/article/10.5101/nbe.v11i4.p340-346 |
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