Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: Role of Na+/K+ ATPase

Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: Role of Na+/K+ ATPase

DJ-1 gene mutations lead to an inherited form of early-onset parkinsonism. The function of DJ-1 is unclear, though a neuroprotective role has been postulated. Electrophysiological recordings were made of striatal and dopaminergic nigral neurons both of wild-type (WT) and DJ-1-knockout (DJ-1−/−) mice...

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Bibliographic Details
Main Authors: A. Pisani, G. Martella, A. Tscherter, C. Costa, N.B. Mercuri, G. Bernardi, J. Shen, P. Calabresi
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Neurobiology of Disease
Subjects:
DJ-1
Parkinson's disease
Electrophysiology
Substantia nigra
Dopamine
Sodium–potassium pump
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000325

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