Transdermal Diagnosis of Malaria Using Vapor Nanobubbles
A fast, precise, noninvasive, high-throughput, and simple approach for detecting malaria in humans and mosquitoes is not possible with current techniques that depend on blood sampling, reagents, facilities, tedious procedures, and trained personnel. We designed a device for rapid (20-second) noninva...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2015-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/21/7/15-0089_article |
| _version_ | 1818186877055795200 |
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| author | Ekaterina Lukianova-Hleb Sarah Bezek Reka Szigeti Alexander Khodarev Thomas Kelley Andrew Hurrell Michail Berba Nirbhay Kumar Umberto D’Alessandro Dmitri Lapotko |
| author_facet | Ekaterina Lukianova-Hleb Sarah Bezek Reka Szigeti Alexander Khodarev Thomas Kelley Andrew Hurrell Michail Berba Nirbhay Kumar Umberto D’Alessandro Dmitri Lapotko |
| author_sort | Ekaterina Lukianova-Hleb |
| collection | DOAJ |
| description | A fast, precise, noninvasive, high-throughput, and simple approach for detecting malaria in humans and mosquitoes is not possible with current techniques that depend on blood sampling, reagents, facilities, tedious procedures, and trained personnel. We designed a device for rapid (20-second) noninvasive diagnosis of Plasmodium falciparum infection in a malaria patient without drawing blood or using any reagent. This method uses transdermal optical excitation and acoustic detection of vapor nanobubbles around intraparasite hemozoin. The same device also identified individual malaria parasite–infected Anopheles mosquitoes in a few seconds and can be realized as a low-cost universal tool for clinical and field diagnoses. |
| first_indexed | 2024-12-11T23:02:07Z |
| format | Article |
| id | doaj.art-a85e2404ca674a528267108d2f87720a |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T23:02:07Z |
| publishDate | 2015-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-a85e2404ca674a528267108d2f87720a2022-12-22T00:47:02ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-07-012171122112710.3201/eid2107.150089Transdermal Diagnosis of Malaria Using Vapor NanobubblesEkaterina Lukianova-HlebSarah BezekReka SzigetiAlexander KhodarevThomas KelleyAndrew HurrellMichail BerbaNirbhay KumarUmberto D’AlessandroDmitri LapotkoA fast, precise, noninvasive, high-throughput, and simple approach for detecting malaria in humans and mosquitoes is not possible with current techniques that depend on blood sampling, reagents, facilities, tedious procedures, and trained personnel. We designed a device for rapid (20-second) noninvasive diagnosis of Plasmodium falciparum infection in a malaria patient without drawing blood or using any reagent. This method uses transdermal optical excitation and acoustic detection of vapor nanobubbles around intraparasite hemozoin. The same device also identified individual malaria parasite–infected Anopheles mosquitoes in a few seconds and can be realized as a low-cost universal tool for clinical and field diagnoses.https://wwwnc.cdc.gov/eid/article/21/7/15-0089_articlemalariabloodlesshemozoinnanobubblelasernoninvasive |
| spellingShingle | Ekaterina Lukianova-Hleb Sarah Bezek Reka Szigeti Alexander Khodarev Thomas Kelley Andrew Hurrell Michail Berba Nirbhay Kumar Umberto D’Alessandro Dmitri Lapotko Transdermal Diagnosis of Malaria Using Vapor Nanobubbles Emerging Infectious Diseases malaria bloodless hemozoin nanobubble laser noninvasive |
| title | Transdermal Diagnosis of Malaria Using Vapor Nanobubbles |
| title_full | Transdermal Diagnosis of Malaria Using Vapor Nanobubbles |
| title_fullStr | Transdermal Diagnosis of Malaria Using Vapor Nanobubbles |
| title_full_unstemmed | Transdermal Diagnosis of Malaria Using Vapor Nanobubbles |
| title_short | Transdermal Diagnosis of Malaria Using Vapor Nanobubbles |
| title_sort | transdermal diagnosis of malaria using vapor nanobubbles |
| topic | malaria bloodless hemozoin nanobubble laser noninvasive |
| url | https://wwwnc.cdc.gov/eid/article/21/7/15-0089_article |
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