Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study
Background: Recent reports have suggested that antihypertensive drugs may play an oncogenic role in common cancers, but it is still uncertain whether this could influence the risk of oral cancer. Through two-sample Mendelian randomization (MR), we sought to assess the causal effect of antihypertensi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1294297/full |
| _version_ | 1797450857732636672 |
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| author | Junfeng Guo Junfeng Guo Rongxing Liu Fangfang Sheng Qiuxiang Wu Rufu Xu Haitao He Gang Zhang Junjie Huang Zhe Zhang Rong Zhang |
| author_facet | Junfeng Guo Junfeng Guo Rongxing Liu Fangfang Sheng Qiuxiang Wu Rufu Xu Haitao He Gang Zhang Junjie Huang Zhe Zhang Rong Zhang |
| author_sort | Junfeng Guo |
| collection | DOAJ |
| description | Background: Recent reports have suggested that antihypertensive drugs may play an oncogenic role in common cancers, but it is still uncertain whether this could influence the risk of oral cancer. Through two-sample Mendelian randomization (MR), we sought to assess the causal effect of antihypertensive drugs on oral cancer outcomes.Methods: To proxy the exposure of antihypertensive drugs, we utilized two genetic instruments, including expression quantitative trait loci of drug target genes and genetic variants within or around drug target genes related to blood pressure from genome-wide association studies. Inverse-variance-weighted MR (IVW-MR) and summary-data-based MR (SMR) were employed to compute the instrument effect estimates.Results: It was observed through IVW-MR analysis that there is a positive relationship between KCNH2 (target of beta-adrenoceptor blockers)–mediated blood pressure and oral cancer (odds ratio [OR] = 1.197, 95% confidence interval [CI] = 1.028–1.394). Similarly, SMR analysis demonstrated that a higher expression of KCNH2 (target of beta-adrenoceptor blockers) was linked to a greater risk of oral cancer (OR = 2.223, 95% CI = 1.094–4.516). Both analyses yielded no consistent evidence of other associations.Conclusion: This two-sample MR study proposed a latent causal association between KCNH2 (target of beta-adrenoceptor blockers) inhibition and diminished risk of oral cancer. |
| first_indexed | 2024-03-09T14:45:37Z |
| format | Article |
| id | doaj.art-a85e99553b8f435bade98eaf6e3e3865 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T14:45:37Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a85e99553b8f435bade98eaf6e3e38652023-11-27T06:42:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.12942971294297Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization studyJunfeng Guo0Junfeng Guo1Rongxing Liu2Fangfang Sheng3Qiuxiang Wu4Rufu Xu5Haitao He6Gang Zhang7Junjie Huang8Zhe Zhang9Rong Zhang10Department of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Stomatology, The 970th Hospital of the Joint Logistics Support Force, Yantai, ChinaDepartment of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, ChinaBackground: Recent reports have suggested that antihypertensive drugs may play an oncogenic role in common cancers, but it is still uncertain whether this could influence the risk of oral cancer. Through two-sample Mendelian randomization (MR), we sought to assess the causal effect of antihypertensive drugs on oral cancer outcomes.Methods: To proxy the exposure of antihypertensive drugs, we utilized two genetic instruments, including expression quantitative trait loci of drug target genes and genetic variants within or around drug target genes related to blood pressure from genome-wide association studies. Inverse-variance-weighted MR (IVW-MR) and summary-data-based MR (SMR) were employed to compute the instrument effect estimates.Results: It was observed through IVW-MR analysis that there is a positive relationship between KCNH2 (target of beta-adrenoceptor blockers)–mediated blood pressure and oral cancer (odds ratio [OR] = 1.197, 95% confidence interval [CI] = 1.028–1.394). Similarly, SMR analysis demonstrated that a higher expression of KCNH2 (target of beta-adrenoceptor blockers) was linked to a greater risk of oral cancer (OR = 2.223, 95% CI = 1.094–4.516). Both analyses yielded no consistent evidence of other associations.Conclusion: This two-sample MR study proposed a latent causal association between KCNH2 (target of beta-adrenoceptor blockers) inhibition and diminished risk of oral cancer.https://www.frontiersin.org/articles/10.3389/fphar.2023.1294297/fullantihypertensive drugsblood pressureoral cancerMendelian randomizationcausal effect |
| spellingShingle | Junfeng Guo Junfeng Guo Rongxing Liu Fangfang Sheng Qiuxiang Wu Rufu Xu Haitao He Gang Zhang Junjie Huang Zhe Zhang Rong Zhang Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study Frontiers in Pharmacology antihypertensive drugs blood pressure oral cancer Mendelian randomization causal effect |
| title | Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study |
| title_full | Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study |
| title_fullStr | Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study |
| title_full_unstemmed | Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study |
| title_short | Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study |
| title_sort | association between antihypertensive drugs and oral cancer a drug target mendelian randomization study |
| topic | antihypertensive drugs blood pressure oral cancer Mendelian randomization causal effect |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1294297/full |
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