Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds
In this study, the biological properties of novel borenium and borinium compounds in terms of their oxidative, genotoxic, and cytotoxic effects were assessed on cultured human peripheral blood cells, as well as several types of cancer cells. Our results revealed that the borinium compounds yielded t...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/11/8/324 |
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| author | Sibel Bayil Oguzkan Hasan Turkez Halil Ibrahim Ugras Arzu Tatar Adil Mardinoglu |
| author_facet | Sibel Bayil Oguzkan Hasan Turkez Halil Ibrahim Ugras Arzu Tatar Adil Mardinoglu |
| author_sort | Sibel Bayil Oguzkan |
| collection | DOAJ |
| description | In this study, the biological properties of novel borenium and borinium compounds in terms of their oxidative, genotoxic, and cytotoxic effects were assessed on cultured human peripheral blood cells, as well as several types of cancer cells. Our results revealed that the borinium compounds yielded the best results in terms of supporting total antioxidant capacity (TAC). In fact, borenium <b>1</b>, borenium <b>2</b>, borenium <b>3</b>, borinium <b>4,</b> and borinium <b>5</b> compounds elevated TAC levels of cultured human blood cells at rates of 42.8%, 101.5%, 69.8%, 33.3%, and 49.2%, respectively. There were no statistically significant differences (<i>p</i> > 0.05) between the negative control and the groups treated with all borinium and borenium concentrations from the micronucleus (MN) and chromosome aberration (CA) assays, demonstrating the non-genotoxic effects. Moreover, borenium <b>1</b> (60.7% and 50.7%), borenium <b>2</b> (70.4% and 57.2%), borenium <b>3</b> (53.1% and 45.2%), borinium <b>4</b> (55.1% and 48.1%), and borinium <b>5</b> (51.0% and 36.1%) minimized the mitomycin C(MMC)-induced genotoxic damages at different rates as determined using CA and MN assays, respectively. Again, it was found that the borinium compounds exhibited higher cytotoxic activity on cancer cells when compared to borenium compounds. Consequently, in light of our in vitro findings, it was suggested that the novel borinium and borenium compounds could be used safely in pharmacology, cosmetics, and various medical fields due to their antioxidant and non-genotoxic features, as well as their cytotoxicity potential on cancer cells. |
| first_indexed | 2024-03-10T23:51:40Z |
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| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-10T23:51:40Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-a86099c6fc6542748b3b73264fc44e372023-11-19T01:35:33ZengMDPI AGInorganics2304-67402023-07-0111832410.3390/inorganics11080324Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium CompoundsSibel Bayil Oguzkan0Hasan Turkez1Halil Ibrahim Ugras2Arzu Tatar3Adil Mardinoglu4Department of Medical Services and Techniques, Vocational School of Health Services, University of Gaziantep, Gaziantep 27410, TurkeyDepartment of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum 25040, TurkeyDepartment of Chemistry, Arts and Science Faculty, Düzce University, Düzce 81620, TurkeyDepartment of Otorhinolaryngology Diseases, Faculty of Medicine, Atatürk University, Erzurum 25040, TurkeyScience for Life Laboratory, KTH-Royal Institute of Technology, 11428 Stockholm, SwedenIn this study, the biological properties of novel borenium and borinium compounds in terms of their oxidative, genotoxic, and cytotoxic effects were assessed on cultured human peripheral blood cells, as well as several types of cancer cells. Our results revealed that the borinium compounds yielded the best results in terms of supporting total antioxidant capacity (TAC). In fact, borenium <b>1</b>, borenium <b>2</b>, borenium <b>3</b>, borinium <b>4,</b> and borinium <b>5</b> compounds elevated TAC levels of cultured human blood cells at rates of 42.8%, 101.5%, 69.8%, 33.3%, and 49.2%, respectively. There were no statistically significant differences (<i>p</i> > 0.05) between the negative control and the groups treated with all borinium and borenium concentrations from the micronucleus (MN) and chromosome aberration (CA) assays, demonstrating the non-genotoxic effects. Moreover, borenium <b>1</b> (60.7% and 50.7%), borenium <b>2</b> (70.4% and 57.2%), borenium <b>3</b> (53.1% and 45.2%), borinium <b>4</b> (55.1% and 48.1%), and borinium <b>5</b> (51.0% and 36.1%) minimized the mitomycin C(MMC)-induced genotoxic damages at different rates as determined using CA and MN assays, respectively. Again, it was found that the borinium compounds exhibited higher cytotoxic activity on cancer cells when compared to borenium compounds. Consequently, in light of our in vitro findings, it was suggested that the novel borinium and borenium compounds could be used safely in pharmacology, cosmetics, and various medical fields due to their antioxidant and non-genotoxic features, as well as their cytotoxicity potential on cancer cells.https://www.mdpi.com/2304-6740/11/8/324antioxidantantigenotoxicityboron compoundsboreniumboriniumcancer cells |
| spellingShingle | Sibel Bayil Oguzkan Hasan Turkez Halil Ibrahim Ugras Arzu Tatar Adil Mardinoglu Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds Inorganics antioxidant antigenotoxicity boron compounds borenium borinium cancer cells |
| title | Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds |
| title_full | Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds |
| title_fullStr | Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds |
| title_full_unstemmed | Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds |
| title_short | Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds |
| title_sort | oxidative genotoxic and cytotoxic damage potential of novel borenium and borinium compounds |
| topic | antioxidant antigenotoxicity boron compounds borenium borinium cancer cells |
| url | https://www.mdpi.com/2304-6740/11/8/324 |
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