Pan-cancer analysis identifies PD-L2 as a tumor promotor in the tumor microenvironment

Pan-cancer analysis identifies PD-L2 as a tumor promotor in the tumor microenvironment

BackgroundProgrammed cell death protein 1 (PD-1) receptor has two ligands,programmed death-ligand 1 (PD-L1) and PD-L2. When compared with PD-L1, PD-L2 has not received much attention, and its role remains unclear.MethodsThe expression profiles of pdcd1lg2 (PD-L2-encoding gene) mRNA and PD-L2 protein...

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Bibliographic Details
Main Authors: Jingfang Lv, Zheng Jiang, Junhu Yuan, Meng Zhuang, Xu Guan, Hengchang Liu, Yefeng Yin, Yiming Ma, Zheng Liu, Hongying Wang, Xishan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint
PD-L2
tumor associated macrophages
colon cancer
pan-cancer analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093716/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093716/full

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