Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
NMDA receptor: Enzyme breaks down ion channel activator in schizophrenic brain Altered metabolism of an amino acid activator of ion channels in the brain could explain dysfunctional nerve signaling in schizophrenia. Researchers in Italy led by Alessandro Usiello from Ceinge Biotecnologie Avanzate an...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-04-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-017-0015-7 |
| _version_ | 1797421480892432384 |
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| author | Tommaso Nuzzo Silvia Sacchi Francesco Errico Simona Keller Orazio Palumbo Ermanno Florio Daniela Punzo Francesco Napolitano Massimiliano Copetti Massimo Carella Lorenzo Chiariotti Alessandro Bertolino Loredano Pollegioni Alessandro Usiello |
| author_facet | Tommaso Nuzzo Silvia Sacchi Francesco Errico Simona Keller Orazio Palumbo Ermanno Florio Daniela Punzo Francesco Napolitano Massimiliano Copetti Massimo Carella Lorenzo Chiariotti Alessandro Bertolino Loredano Pollegioni Alessandro Usiello |
| author_sort | Tommaso Nuzzo |
| collection | DOAJ |
| description | NMDA receptor: Enzyme breaks down ion channel activator in schizophrenic brain Altered metabolism of an amino acid activator of ion channels in the brain could explain dysfunctional nerve signaling in schizophrenia. Researchers in Italy led by Alessandro Usiello from Ceinge Biotecnologie Avanzate and Loredano Pollegioni from the University of Insubria measured the levels of two amino acids—D-aspartate and D-serine—in post-mortem tissues taken from two brain regions of patients with and without schizophrenia. Both amino acids activate the N-methyl D-aspartate receptor, which is known to be less active in people with schizophrenia. The researchers found a mild increase in D-serine levels but a major decrease in D-aspartate in the schizophrenia patients’ dorsolateral prefrontal cortex (DLPFC), a memory and reasoning part of the brain, but not in the hippocampus. They also documented a greater activity of the enzyme responsible for D-aspartate breakdown in the DLPFC. |
| first_indexed | 2024-03-09T07:18:06Z |
| format | Article |
| id | doaj.art-a86308ddf58444f9aee77aabea30e675 |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-09T07:18:06Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-a86308ddf58444f9aee77aabea30e6752023-12-03T08:22:27ZengNature Portfolionpj Schizophrenia2334-265X2017-04-013111010.1038/s41537-017-0015-7Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patientsTommaso Nuzzo0Silvia Sacchi1Francesco Errico2Simona Keller3Orazio Palumbo4Ermanno Florio5Daniela Punzo6Francesco Napolitano7Massimiliano Copetti8Massimo Carella9Lorenzo Chiariotti10Alessandro Bertolino11Loredano Pollegioni12Alessandro Usiello13Laboratory of Behavioral Neuroscience, Ceinge Biotecnologie AvanzateDepartment of Biotechnology and Life Sciences, University of InsubriaLaboratory of Behavioral Neuroscience, Ceinge Biotecnologie AvanzateDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”Medical Genetics Unit, IRCCS Casa Sollievo della SofferenzaDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”Laboratory of Behavioral Neuroscience, Ceinge Biotecnologie AvanzateLaboratory of Behavioral Neuroscience, Ceinge Biotecnologie AvanzateUnit of Biostatistics, IRCCS Casa Sollievo della SofferenzaMedical Genetics Unit, IRCCS Casa Sollievo della SofferenzaDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari “Aldo Moro”Department of Biotechnology and Life Sciences, University of InsubriaLaboratory of Behavioral Neuroscience, Ceinge Biotecnologie AvanzateNMDA receptor: Enzyme breaks down ion channel activator in schizophrenic brain Altered metabolism of an amino acid activator of ion channels in the brain could explain dysfunctional nerve signaling in schizophrenia. Researchers in Italy led by Alessandro Usiello from Ceinge Biotecnologie Avanzate and Loredano Pollegioni from the University of Insubria measured the levels of two amino acids—D-aspartate and D-serine—in post-mortem tissues taken from two brain regions of patients with and without schizophrenia. Both amino acids activate the N-methyl D-aspartate receptor, which is known to be less active in people with schizophrenia. The researchers found a mild increase in D-serine levels but a major decrease in D-aspartate in the schizophrenia patients’ dorsolateral prefrontal cortex (DLPFC), a memory and reasoning part of the brain, but not in the hippocampus. They also documented a greater activity of the enzyme responsible for D-aspartate breakdown in the DLPFC.https://doi.org/10.1038/s41537-017-0015-7 |
| spellingShingle | Tommaso Nuzzo Silvia Sacchi Francesco Errico Simona Keller Orazio Palumbo Ermanno Florio Daniela Punzo Francesco Napolitano Massimiliano Copetti Massimo Carella Lorenzo Chiariotti Alessandro Bertolino Loredano Pollegioni Alessandro Usiello Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients npj Schizophrenia |
| title | Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients |
| title_full | Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients |
| title_fullStr | Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients |
| title_full_unstemmed | Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients |
| title_short | Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients |
| title_sort | decreased free d aspartate levels are linked to enhanced d aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients |
| url | https://doi.org/10.1038/s41537-017-0015-7 |
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