Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronate
Aim. To study fractional composition of red cell membrane (RCM) lipids in patients with severe iron-deficiency anemia (IDA) complicated by myocardiodystrophy prior to treatment and after 1-month combined treatment with sorbifer and mildronate. Material and methods. Fatty acid composition of RCM lipi...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2008-06-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30203 |
| _version_ | 1818258373501517824 |
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| author | E V Goncharova A V Govorin |
| author_facet | E V Goncharova A V Govorin |
| author_sort | E V Goncharova |
| collection | DOAJ |
| description | Aim. To study fractional composition of red cell membrane (RCM) lipids in patients with severe iron-deficiency anemia (IDA) complicated by myocardiodystrophy prior to treatment and after 1-month combined treatment with sorbifer and mildronate. Material and methods. Fatty acid composition of RCM lipids was studied in 12 patients with severe chronic posthemorrhagic IDA complicated by myocardiodystrophy and in 15 healthy subjects. Extraction of lipids from blood red cells and methylation of fatty acids were performed according to K.M. Sinyak et al. (1976). Relative content of fatty acids was determined at chromatography. Results. The study detected increased content of saturated fatty acids, especially palmitic and decreased content of unsaturated fatty acids especially fraction of omega6-polyunsaturated fatty acids: arachidonic and gamma-linolenic. Conclusion. Sorbifer in combination with mildronate improved fatty acid composition of blood red cells in patients with iron-deficiency anemia. |
| first_indexed | 2024-12-12T17:58:31Z |
| format | Article |
| id | doaj.art-a8656c1e68b844ce818fdffd9f019ec5 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-12T17:58:31Z |
| publishDate | 2008-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-a8656c1e68b844ce818fdffd9f019ec52022-12-22T00:16:40Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422008-06-01806656827230Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronateE V GoncharovaA V GovorinAim. To study fractional composition of red cell membrane (RCM) lipids in patients with severe iron-deficiency anemia (IDA) complicated by myocardiodystrophy prior to treatment and after 1-month combined treatment with sorbifer and mildronate. Material and methods. Fatty acid composition of RCM lipids was studied in 12 patients with severe chronic posthemorrhagic IDA complicated by myocardiodystrophy and in 15 healthy subjects. Extraction of lipids from blood red cells and methylation of fatty acids were performed according to K.M. Sinyak et al. (1976). Relative content of fatty acids was determined at chromatography. Results. The study detected increased content of saturated fatty acids, especially palmitic and decreased content of unsaturated fatty acids especially fraction of omega6-polyunsaturated fatty acids: arachidonic and gamma-linolenic. Conclusion. Sorbifer in combination with mildronate improved fatty acid composition of blood red cells in patients with iron-deficiency anemia.https://ter-arkhiv.ru/0040-3660/article/view/30203fatty acidsiron deficiency anemi |
| spellingShingle | E V Goncharova A V Govorin Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronate Терапевтический архив fatty acids iron deficiency anemi |
| title | Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronate |
| title_full | Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronate |
| title_fullStr | Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronate |
| title_full_unstemmed | Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronate |
| title_short | Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronate |
| title_sort | changes in fatty acids content in blood red cells of patients with iron deficiency anemia treated with sorbifer and mildronate |
| topic | fatty acids iron deficiency anemi |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30203 |
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