Challenges of COPD Patients during the COVID-19 Pandemic
Coronavirus disease 2019 (COVID-19) is a severe systemic infection that is a major threat to healthcare systems worldwide. According to studies, chronic obstructive pulmonary disease (COPD) patients with COVID-19 usually have a high risk of developing severe symptoms and fatality, but limited resear...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/11/12/1484 |
| _version_ | 1797455818365337600 |
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| author | Sheng-Wen Sun Chang Qi Xian-Zhi Xiong |
| author_facet | Sheng-Wen Sun Chang Qi Xian-Zhi Xiong |
| author_sort | Sheng-Wen Sun |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is a severe systemic infection that is a major threat to healthcare systems worldwide. According to studies, chronic obstructive pulmonary disease (COPD) patients with COVID-19 usually have a high risk of developing severe symptoms and fatality, but limited research has addressed the poor condition of COPD patients during the pandemic. This review focuses on the underlying risk factors including innate immune dysfunction, angiotensin converting enzyme 2 (ACE2) expression, smoking status, precocious differentiation of T lymphocytes and immunosenescence in COPD patients which might account for their poor outcomes during the COVID-19 crisis. Furthermore, we highlight the role of aging of the immune system, which may be the culprit of COVID-19. In brief, we list the challenges of COPD patients in this national pandemic, aiming to provide immune-related considerations to support critical processes in COPD patients during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and inspire immune therapy for these patients. |
| first_indexed | 2024-03-09T15:59:34Z |
| format | Article |
| id | doaj.art-a8659c3891254a0ea1b301868130d0be |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T15:59:34Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-a8659c3891254a0ea1b301868130d0be2023-11-24T17:13:30ZengMDPI AGPathogens2076-08172022-12-011112148410.3390/pathogens11121484Challenges of COPD Patients during the COVID-19 PandemicSheng-Wen Sun0Chang Qi1Xian-Zhi Xiong2Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, ChinaDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, ChinaDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, ChinaCoronavirus disease 2019 (COVID-19) is a severe systemic infection that is a major threat to healthcare systems worldwide. According to studies, chronic obstructive pulmonary disease (COPD) patients with COVID-19 usually have a high risk of developing severe symptoms and fatality, but limited research has addressed the poor condition of COPD patients during the pandemic. This review focuses on the underlying risk factors including innate immune dysfunction, angiotensin converting enzyme 2 (ACE2) expression, smoking status, precocious differentiation of T lymphocytes and immunosenescence in COPD patients which might account for their poor outcomes during the COVID-19 crisis. Furthermore, we highlight the role of aging of the immune system, which may be the culprit of COVID-19. In brief, we list the challenges of COPD patients in this national pandemic, aiming to provide immune-related considerations to support critical processes in COPD patients during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and inspire immune therapy for these patients.https://www.mdpi.com/2076-0817/11/12/1484COVID-19COPDACE2precocious differentiation of T cellsimmunosenescence |
| spellingShingle | Sheng-Wen Sun Chang Qi Xian-Zhi Xiong Challenges of COPD Patients during the COVID-19 Pandemic Pathogens COVID-19 COPD ACE2 precocious differentiation of T cells immunosenescence |
| title | Challenges of COPD Patients during the COVID-19 Pandemic |
| title_full | Challenges of COPD Patients during the COVID-19 Pandemic |
| title_fullStr | Challenges of COPD Patients during the COVID-19 Pandemic |
| title_full_unstemmed | Challenges of COPD Patients during the COVID-19 Pandemic |
| title_short | Challenges of COPD Patients during the COVID-19 Pandemic |
| title_sort | challenges of copd patients during the covid 19 pandemic |
| topic | COVID-19 COPD ACE2 precocious differentiation of T cells immunosenescence |
| url | https://www.mdpi.com/2076-0817/11/12/1484 |
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