Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes
We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2017-10-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0086 |
| _version_ | 1819109828303257600 |
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| author | S Hussain S Keat S V Gelding |
| author_facet | S Hussain S Keat S V Gelding |
| author_sort | S Hussain |
| collection | DOAJ |
| description | We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). However, the diagnosis of SLE prompted testing for an autoimmune aetiology for the diabetes, and she was found to have a very high titre of GAD antibodies. Typical type 1 diabetes (T1D) was thought unlikely due to the long preceding history of GDM. Latent autoimmune diabetes of adults (LADA) was considered, but ruled out as she required insulin therapy from diagnosis. The challenge of identifying the type of diabetes when clinical features overlap the various diabetes categories is discussed. This is the first report of autoimmune ketosis-prone diabetes (KPD) presenting with new onset of SLE. |
| first_indexed | 2024-12-22T03:32:01Z |
| format | Article |
| id | doaj.art-a8682ba31054483b9effd77e72070c86 |
| institution | Directory Open Access Journal |
| issn | 2052-0573 2052-0573 |
| language | English |
| last_indexed | 2024-12-22T03:32:01Z |
| publishDate | 2017-10-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-a8682ba31054483b9effd77e72070c862022-12-21T18:40:28ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732052-05732017-10-01111510.1530/EDM-17-0086Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetesS Hussain0S Keat1S V Gelding2Department of Diabetes and Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UKDepartment of Diabetes and Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UKDepartment of Diabetes and Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UKWe describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). However, the diagnosis of SLE prompted testing for an autoimmune aetiology for the diabetes, and she was found to have a very high titre of GAD antibodies. Typical type 1 diabetes (T1D) was thought unlikely due to the long preceding history of GDM. Latent autoimmune diabetes of adults (LADA) was considered, but ruled out as she required insulin therapy from diagnosis. The challenge of identifying the type of diabetes when clinical features overlap the various diabetes categories is discussed. This is the first report of autoimmune ketosis-prone diabetes (KPD) presenting with new onset of SLE.https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0086 |
| spellingShingle | S Hussain S Keat S V Gelding Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes Endocrinology, Diabetes & Metabolism Case Reports |
| title | Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes |
| title_full | Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes |
| title_fullStr | Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes |
| title_full_unstemmed | Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes |
| title_short | Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes |
| title_sort | ketosis prone diabetes and sle co presenting in an african lady with previous gestational diabetes |
| url | https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0086 |
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