Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female rats
Stress-related neuropsychiatric disorders affect nearly all people worldwide irrespective of the age and sex of the person. Females are supposed to experience a higher stress and anxiety as compared to the male individuals. The role of serotonin receptor in stress and anxiety condition is supposed t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022015304 |
| _version_ | 1818009981657546752 |
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| author | Sarfraj Ahmad Siddiqui Sanjay Singh Atul Rawat Md Arshad Sudhir Kumar |
| author_facet | Sarfraj Ahmad Siddiqui Sanjay Singh Atul Rawat Md Arshad Sudhir Kumar |
| author_sort | Sarfraj Ahmad Siddiqui |
| collection | DOAJ |
| description | Stress-related neuropsychiatric disorders affect nearly all people worldwide irrespective of the age and sex of the person. Females are supposed to experience a higher stress and anxiety as compared to the male individuals. The role of serotonin receptor in stress and anxiety condition is supposed to affect this sex-based difference in stress and anxiety condition between male and female animals. Serotonin receptor system is one of the most important molecular mechanism in brain function involved in a number of vital functions such as apetite, sleep, thermoregulation, aggression, learning, mood, cognition as well as in stress and anxiety. The current preclinical study is analyzing the role of serotonin 5HT-5A and 5B receptor in stress and anxiety in male and female rodents. The study suggests here a differential region specific association of both the serotonin receptor under stressful condition between male and female animals. |
| first_indexed | 2024-04-14T05:49:36Z |
| format | Article |
| id | doaj.art-a868bc8707fe44d0af24e6ec8d6b0371 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-14T05:49:36Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-a868bc8707fe44d0af24e6ec8d6b03712022-12-22T02:09:10ZengElsevierHeliyon2405-84402022-08-0188e10242Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female ratsSarfraj Ahmad Siddiqui0Sanjay Singh1Atul Rawat2Md Arshad3Sudhir Kumar4Department of Zoology, University of Lucknow, Lucknow, India; Corresponding author.Department of Biotechnology, BBAU, Lucknow, IndiaDepartment of Biotechnology, BBAU, Lucknow, IndiaDepartment of Zoology, Aligarh Muslim University, Aligarh, IndiaDepartment of Zoology, University of Lucknow, Lucknow, IndiaStress-related neuropsychiatric disorders affect nearly all people worldwide irrespective of the age and sex of the person. Females are supposed to experience a higher stress and anxiety as compared to the male individuals. The role of serotonin receptor in stress and anxiety condition is supposed to affect this sex-based difference in stress and anxiety condition between male and female animals. Serotonin receptor system is one of the most important molecular mechanism in brain function involved in a number of vital functions such as apetite, sleep, thermoregulation, aggression, learning, mood, cognition as well as in stress and anxiety. The current preclinical study is analyzing the role of serotonin 5HT-5A and 5B receptor in stress and anxiety in male and female rodents. The study suggests here a differential region specific association of both the serotonin receptor under stressful condition between male and female animals.http://www.sciencedirect.com/science/article/pii/S2405844022015304Serotonin5HTStressAnxietySexSerotonin receptors |
| spellingShingle | Sarfraj Ahmad Siddiqui Sanjay Singh Atul Rawat Md Arshad Sudhir Kumar Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female rats Heliyon Serotonin 5HT Stress Anxiety Sex Serotonin receptors |
| title | Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female rats |
| title_full | Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female rats |
| title_fullStr | Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female rats |
| title_full_unstemmed | Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female rats |
| title_short | Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female rats |
| title_sort | region specific differential regulation of 5ht 5a and 5b receptor is associated with the difference in stress level between male and female rats |
| topic | Serotonin 5HT Stress Anxiety Sex Serotonin receptors |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022015304 |
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