The brain of teleost fish, a source and a target of sexual steroids
Neurosteroids are defined as steroids de novo synthesized in the central nervous system. While the production of neurosteroids is well documented in mammals or amphibians, there is little information in teleosts, the largest group of fish. Teleosts have long been known for their high brain aromatase...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-12-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2011.00137/full |
| _version_ | 1828492897455964160 |
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| author | Nicolas eDiotel Jean-Luc eDo-Rego Isabelle eAnglade Colette eVaillant Elisabeth ePellegrini Hubert eVaudry Olivier eKah |
| author_facet | Nicolas eDiotel Jean-Luc eDo-Rego Isabelle eAnglade Colette eVaillant Elisabeth ePellegrini Hubert eVaudry Olivier eKah |
| author_sort | Nicolas eDiotel |
| collection | DOAJ |
| description | Neurosteroids are defined as steroids de novo synthesized in the central nervous system. While the production of neurosteroids is well documented in mammals or amphibians, there is little information in teleosts, the largest group of fish. Teleosts have long been known for their high brain aromatase and 5α-reductase activities, but recent data now document the capacity of the brain of fish to produce a large variety of sex steroids. This article aims at reviewing the available information regarding expression and/or activity of the main steroidogenic enzymes in the brain of fish. In addition, the distribution of estrogen, androgen and progesterone nuclear receptors is documented in relation with the potential sites of production of neurosteroids. Interestingly, radial glial cells acting as neuronal progenitors, appear to be a potential source of neurosteroids, but also a target for centrally and/or peripherally produced steroids. |
| first_indexed | 2024-12-11T11:29:52Z |
| format | Article |
| id | doaj.art-a86a07b30b314c78b18a705bf8481d7e |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T11:29:52Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-a86a07b30b314c78b18a705bf8481d7e2022-12-22T01:08:55ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2011-12-01510.3389/fnins.2011.0013719145The brain of teleost fish, a source and a target of sexual steroidsNicolas eDiotel0Jean-Luc eDo-Rego1Isabelle eAnglade2Colette eVaillant3Elisabeth ePellegrini4Hubert eVaudry5Olivier eKah6CNRS UMR 6026INSERM U982, PRIMACEN, IFRMP 23CNRS UMR 6026CNRS UMR 6026CNRS UMR 6026INSERM U982, PRIMACEN, IFRMP 23CNRS UMR 6026Neurosteroids are defined as steroids de novo synthesized in the central nervous system. While the production of neurosteroids is well documented in mammals or amphibians, there is little information in teleosts, the largest group of fish. Teleosts have long been known for their high brain aromatase and 5α-reductase activities, but recent data now document the capacity of the brain of fish to produce a large variety of sex steroids. This article aims at reviewing the available information regarding expression and/or activity of the main steroidogenic enzymes in the brain of fish. In addition, the distribution of estrogen, androgen and progesterone nuclear receptors is documented in relation with the potential sites of production of neurosteroids. Interestingly, radial glial cells acting as neuronal progenitors, appear to be a potential source of neurosteroids, but also a target for centrally and/or peripherally produced steroids.http://journal.frontiersin.org/Journal/10.3389/fnins.2011.00137/fullAromataseZebrafishneurosteroidteleost3β-HSDCYP17 |
| spellingShingle | Nicolas eDiotel Jean-Luc eDo-Rego Isabelle eAnglade Colette eVaillant Elisabeth ePellegrini Hubert eVaudry Olivier eKah The brain of teleost fish, a source and a target of sexual steroids Frontiers in Neuroscience Aromatase Zebrafish neurosteroid teleost 3β-HSD CYP17 |
| title | The brain of teleost fish, a source and a target of sexual steroids |
| title_full | The brain of teleost fish, a source and a target of sexual steroids |
| title_fullStr | The brain of teleost fish, a source and a target of sexual steroids |
| title_full_unstemmed | The brain of teleost fish, a source and a target of sexual steroids |
| title_short | The brain of teleost fish, a source and a target of sexual steroids |
| title_sort | brain of teleost fish a source and a target of sexual steroids |
| topic | Aromatase Zebrafish neurosteroid teleost 3β-HSD CYP17 |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2011.00137/full |
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