Immune response stability to the SARS-CoV-2 mRNA vaccine booster is influenced by differential splicing of HLA genes

Immune response stability to the SARS-CoV-2 mRNA vaccine booster is influenced by differential splicing of HLA genes

Abstract Many molecular mechanisms that lead to the host antibody response to COVID-19 vaccines remain largely unknown. In this study, we used serum antibody detection combined with whole blood RNA-based transcriptome analysis to investigate variability in vaccine response in healthy recipients of a...

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Bibliographic Details
Main Authors: Cíntia Barros Santos-Rebouças, Cristina dos Santos Ferreira, Jeane de Souza Nogueira, Otávio José Brustolini, Luiz Gonzaga Paula de Almeida, Alexandra Lehmkuhl Gerber, Ana Paula de Campos Guimarães, Rafael Mina Piergiorge, Cláudio José Struchiner, Luís Cristóvão Porto, Ana Tereza Ribeiro de Vasconcelos
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
SARS-CoV-2
Vaccine response
Whole blood transcriptome
Immune response variability
Admixed population
Human leukocyte antigen
Online Access:https://doi.org/10.1038/s41598-024-59259-1

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