Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists

Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists

Abstract Peroxisome proliferator-activated receptor-γ (PPAR-γ) partial agonists or antagonists, also termed as selective PPAR-γ modulators, are more beneficial than full agonists because they can avoid the adverse effects associated with PPAR-γ full agonists, such as weight gain and congestive heart...

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Bibliographic Details
Main Authors: Asim Najmi, Md Shamsher Alam, Neelaveni Thangavel, Manal M. E. Taha, Abdulkarim M. Meraya, Mohammed Albratty, Hassan A. Alhazmi, Waquar Ahsan, Anzarul Haque, Faizul Azam
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47157-x

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