Boulton-Katritzky Rearrangement of 5-Substituted Phenyl-3-[2-(morpholin-1-yl)ethyl]-1,2,4-oxadiazoles as a Synthetic Path to Spiropyrazoline Benzoates and Chloride with Antitubercular Properties

Boulton-Katritzky Rearrangement of 5-Substituted Phenyl-3-[2-(morpholin-1-yl)ethyl]-1,2,4-oxadiazoles as a Synthetic Path to Spiropyrazoline Benzoates and Chloride with Antitubercular Properties

The analysis of stability of biologically active compounds requires an accurate determination of their structure. We have found that 5-aryl-3-(2-aminoethyl)-1,2,4-oxadiazoles are generally unstable in the presence of acids and bases and are rearranged into the salts of spiropyrazolinium compounds. H...

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Bibliographic Details
Main Authors: Lyudmila Kayukova, Anna Vologzhanina, Kaldybai Praliyev, Gulnur Dyusembaeva, Gulnur Baitursynova, Asem Uzakova, Venera Bismilda, Lyailya Chingissova, Kydyrmolla Akatan
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
1,2,4-oxadiazoles
spiropyrazolinium compounds
in vitro antitubercular screening
X-ray diffraction
molecular docking
Online Access:https://www.mdpi.com/1420-3049/26/4/967

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