MicroRNAs : An Emerging Player In Autophagy
Autophagy is an evolutionarily conserved self-digestion process for the quality control of intracellular entities in eukaryotes. In the past few years, mounting evidence indicates that microRNAs (miRNAs)-mediated post-transcriptional regulation of gene expression represents an integral part of the a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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ScienceOpen
2014-11-01
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| Series: | ScienceOpen Research |
| Online Access: | https://www.scienceopen.com/document?vid=dfcd3b09-eb66-454f-ae5c-19894f1eb382 |
| _version_ | 1827106570171842560 |
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| author | yongfei yang CHENGYU LIANG |
| author_facet | yongfei yang CHENGYU LIANG |
| author_sort | yongfei yang |
| collection | DOAJ |
| description | Autophagy is an evolutionarily conserved self-digestion process for the quality control of intracellular entities in eukaryotes. In the past few years, mounting evidence indicates that microRNAs (miRNAs)-mediated post-transcriptional regulation of gene expression represents an integral part of the autophagy regulatory network and may have a substantial effect on autophagy-related physiological and pathological conditions including cancer. Herein, we examine some of the molecular mechanisms by which microRNAs manipulate the autophagic machinery to maintain cellular homeostasis and their biological outputs during cancer development. A better understanding of interaction between microRNAs and cellular autophagy may ultimately benefit future cancer diagnostic and anticancer therapeutics. |
| first_indexed | 2024-04-10T07:50:08Z |
| format | Article |
| id | doaj.art-a8734a0b0cf04f1ab36088aeb08bf8f3 |
| institution | Directory Open Access Journal |
| issn | 2199-1006 |
| language | English |
| last_indexed | 2025-03-20T09:56:49Z |
| publishDate | 2014-11-01 |
| publisher | ScienceOpen |
| record_format | Article |
| series | ScienceOpen Research |
| spelling | doaj.art-a8734a0b0cf04f1ab36088aeb08bf8f32024-09-24T17:21:16ZengScienceOpenScienceOpen Research2199-10062014-11-0110.14293/S2199-1006.1.SOR-LIFE.A181CU.v1MicroRNAs : An Emerging Player In Autophagyyongfei yangCHENGYU LIANGAutophagy is an evolutionarily conserved self-digestion process for the quality control of intracellular entities in eukaryotes. In the past few years, mounting evidence indicates that microRNAs (miRNAs)-mediated post-transcriptional regulation of gene expression represents an integral part of the autophagy regulatory network and may have a substantial effect on autophagy-related physiological and pathological conditions including cancer. Herein, we examine some of the molecular mechanisms by which microRNAs manipulate the autophagic machinery to maintain cellular homeostasis and their biological outputs during cancer development. A better understanding of interaction between microRNAs and cellular autophagy may ultimately benefit future cancer diagnostic and anticancer therapeutics.https://www.scienceopen.com/document?vid=dfcd3b09-eb66-454f-ae5c-19894f1eb382 |
| spellingShingle | yongfei yang CHENGYU LIANG MicroRNAs : An Emerging Player In Autophagy ScienceOpen Research |
| title | MicroRNAs : An Emerging Player In Autophagy |
| title_full | MicroRNAs : An Emerging Player In Autophagy |
| title_fullStr | MicroRNAs : An Emerging Player In Autophagy |
| title_full_unstemmed | MicroRNAs : An Emerging Player In Autophagy |
| title_short | MicroRNAs : An Emerging Player In Autophagy |
| title_sort | micrornas an emerging player in autophagy |
| url | https://www.scienceopen.com/document?vid=dfcd3b09-eb66-454f-ae5c-19894f1eb382 |
| work_keys_str_mv | AT yongfeiyang micrornasanemergingplayerinautophagy AT chengyuliang micrornasanemergingplayerinautophagy |