| Summary: | Inflammation is related to many diseases. <em>Lindera akoensis</em> Hayata was often used in folk<br />therapy in Taiwan for inflammation. In this study, three new flavonol acyl glycosides, namely<br />kaempferol-3-O--D-4”,6”-di-(E)-p-coumaroylglucoside (<strong>1</strong>), 3”-(E)-p-coumaroylafzelin (<strong>2</strong>) and 40-Omethyl-<br />2”,4”-di-(E)-p-coumaroylquercitrin (<strong>3</strong>), and three components, 3-dodecyl-4-hydroxy-<br />5-methyldihydrofuran-2-one (<strong>4</strong>), 2-acetoxyclovan-9-ol (<strong>5</strong>), (1,4,6)-trihydroxyeudesmane<br />(<strong>6</strong>) that were isolated from the natural product for the first time were obtained along with 25 known<br />compounds from <em>L. akoensis</em>. Their structures were determined by comprehensive spectroscopic<br />analyses (1D and 2D NMR, EI-, ESI- and HRESI-MS). The ability of 1 to decrease the LPS-stimulated<br />production of nitrite in RAW264.7 cell was evaluated, showing an IC<sub>50</sub> value of 36.3 ± 3.2 μM.<br />This result supports the value of <em>L. akoensis</em> as a traditional medicine resource.
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