New Anti-inflammatory Flavonol Glycosides from <em>Lindera akoensis</em> Hayata
Inflammation is related to many diseases. <em>Lindera akoensis</em> Hayata was often used in folk<br />therapy in Taiwan for inflammation. In this study, three new flavonol acyl glycosides, namely<br />kaempferol-3-O--D-4”,6”-di-(E)-p-coumaroylglucoside (<strong>1</s...
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MDPI AG
2019-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/3/563 |
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| author | Chung-Ping Yang Pei-Hsin Shie Guan-Jhong Huang Shih-Chang Chien Yueh-Hsiung Kuo |
| author_facet | Chung-Ping Yang Pei-Hsin Shie Guan-Jhong Huang Shih-Chang Chien Yueh-Hsiung Kuo |
| author_sort | Chung-Ping Yang |
| collection | DOAJ |
| description | Inflammation is related to many diseases. <em>Lindera akoensis</em> Hayata was often used in folk<br />therapy in Taiwan for inflammation. In this study, three new flavonol acyl glycosides, namely<br />kaempferol-3-O--D-4”,6”-di-(E)-p-coumaroylglucoside (<strong>1</strong>), 3”-(E)-p-coumaroylafzelin (<strong>2</strong>) and 40-Omethyl-<br />2”,4”-di-(E)-p-coumaroylquercitrin (<strong>3</strong>), and three components, 3-dodecyl-4-hydroxy-<br />5-methyldihydrofuran-2-one (<strong>4</strong>), 2-acetoxyclovan-9-ol (<strong>5</strong>), (1,4,6)-trihydroxyeudesmane<br />(<strong>6</strong>) that were isolated from the natural product for the first time were obtained along with 25 known<br />compounds from <em>L. akoensis</em>. Their structures were determined by comprehensive spectroscopic<br />analyses (1D and 2D NMR, EI-, ESI- and HRESI-MS). The ability of 1 to decrease the LPS-stimulated<br />production of nitrite in RAW264.7 cell was evaluated, showing an IC<sub>50</sub> value of 36.3 ± 3.2 μM.<br />This result supports the value of <em>L. akoensis</em> as a traditional medicine resource. |
| first_indexed | 2024-12-11T23:00:54Z |
| format | Article |
| id | doaj.art-a8737047cc14464c9c50f28dc84421f1 |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T23:00:54Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a8737047cc14464c9c50f28dc84421f12022-12-22T00:47:04ZengMDPI AGMolecules1420-30492019-02-0124356310.3390/molecules24030563molecules24030563New Anti-inflammatory Flavonol Glycosides from <em>Lindera akoensis</em> HayataChung-Ping Yang0Pei-Hsin Shie1Guan-Jhong Huang2Shih-Chang Chien3Yueh-Hsiung Kuo4Key Laboratory of Preventive Veterinary Medicine and Biotechnology, Longyan University,Longyan 364012, ChinaKey Laboratory of Preventive Veterinary Medicine and Biotechnology, Longyan University,Longyan 364012, ChinaDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University,Taichung 404, TaiwanThe Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, TaiwanDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University,Taichung 404, TaiwanInflammation is related to many diseases. <em>Lindera akoensis</em> Hayata was often used in folk<br />therapy in Taiwan for inflammation. In this study, three new flavonol acyl glycosides, namely<br />kaempferol-3-O--D-4”,6”-di-(E)-p-coumaroylglucoside (<strong>1</strong>), 3”-(E)-p-coumaroylafzelin (<strong>2</strong>) and 40-Omethyl-<br />2”,4”-di-(E)-p-coumaroylquercitrin (<strong>3</strong>), and three components, 3-dodecyl-4-hydroxy-<br />5-methyldihydrofuran-2-one (<strong>4</strong>), 2-acetoxyclovan-9-ol (<strong>5</strong>), (1,4,6)-trihydroxyeudesmane<br />(<strong>6</strong>) that were isolated from the natural product for the first time were obtained along with 25 known<br />compounds from <em>L. akoensis</em>. Their structures were determined by comprehensive spectroscopic<br />analyses (1D and 2D NMR, EI-, ESI- and HRESI-MS). The ability of 1 to decrease the LPS-stimulated<br />production of nitrite in RAW264.7 cell was evaluated, showing an IC<sub>50</sub> value of 36.3 ± 3.2 μM.<br />This result supports the value of <em>L. akoensis</em> as a traditional medicine resource.https://www.mdpi.com/1420-3049/24/3/563<em>Lindera akoensis</em>flavonol glycosideanti-inflammatory |
| spellingShingle | Chung-Ping Yang Pei-Hsin Shie Guan-Jhong Huang Shih-Chang Chien Yueh-Hsiung Kuo New Anti-inflammatory Flavonol Glycosides from <em>Lindera akoensis</em> Hayata Molecules <em>Lindera akoensis</em> flavonol glycoside anti-inflammatory |
| title | New Anti-inflammatory Flavonol Glycosides from <em>Lindera akoensis</em> Hayata |
| title_full | New Anti-inflammatory Flavonol Glycosides from <em>Lindera akoensis</em> Hayata |
| title_fullStr | New Anti-inflammatory Flavonol Glycosides from <em>Lindera akoensis</em> Hayata |
| title_full_unstemmed | New Anti-inflammatory Flavonol Glycosides from <em>Lindera akoensis</em> Hayata |
| title_short | New Anti-inflammatory Flavonol Glycosides from <em>Lindera akoensis</em> Hayata |
| title_sort | new anti inflammatory flavonol glycosides from em lindera akoensis em hayata |
| topic | <em>Lindera akoensis</em> flavonol glycoside anti-inflammatory |
| url | https://www.mdpi.com/1420-3049/24/3/563 |
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