The implications of DNA methylation for amyotrophic lateral sclerosis
Abstract Amyotrophic lateral sclerosis (ALS) is a complex and serious neurodegenerative disorder that develops in consequence of the progressive loss of the upper and lower motor neurons. Cases of ALS are classified as sporadic (sALS), or familial (fALS). Over 90% of cases are sALS, while roughly 10...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2023-10-01
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| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000500801&lng=en&tlng=en |
| _version_ | 1797644501787869184 |
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| author | ADRIANA HELENA DE OLIVEIRA REIS LUNA B. FIGALO MARCO ORSINI BERNARDO LEMOS |
| author_facet | ADRIANA HELENA DE OLIVEIRA REIS LUNA B. FIGALO MARCO ORSINI BERNARDO LEMOS |
| author_sort | ADRIANA HELENA DE OLIVEIRA REIS |
| collection | DOAJ |
| description | Abstract Amyotrophic lateral sclerosis (ALS) is a complex and serious neurodegenerative disorder that develops in consequence of the progressive loss of the upper and lower motor neurons. Cases of ALS are classified as sporadic (sALS), or familial (fALS). Over 90% of cases are sALS, while roughly 10% are related to inherited genetic mutations (fALS). Approximately 70% of the genetic mutations that contribute to fALS have been identified. On the other hand, the majority of the sALS cases have an undetermined genetic contributor and few mutations have been described, despite the advanced genetic analysis methods. Also, several factors contribute to the onset and progression of ALS. Numerous lines of evidence indicate that epigenetic changes are linked to aging, as well as neurodegenerative disorders, such as ALS. In most cases, they act as the heritable regulation of transcription by DNA methylation, histone modification and expression of noncoding RNAs. Mechanisms involving aberrant DNA methylation could be relevant to human ALS pathobiology and therapeutic targeting. Despite advances in research to find factors associated with ALS and more effective treatments, this disease remains complex and has low patient survival. Here, we provide a narrative review of the role of DNA methylation for this complex neurodegenerative disorder. |
| first_indexed | 2024-03-11T14:31:23Z |
| format | Article |
| id | doaj.art-a87764f1498842899f7e9cfdb2ee1444 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-03-11T14:31:23Z |
| publishDate | 2023-10-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-a87764f1498842899f7e9cfdb2ee14442023-10-31T07:54:01ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902023-10-0195suppl 210.1590/0001-3765202320230277The implications of DNA methylation for amyotrophic lateral sclerosisADRIANA HELENA DE OLIVEIRA REIShttps://orcid.org/0000-0001-7458-131XLUNA B. FIGALOhttps://orcid.org/0000-0002-7017-5880MARCO ORSINIhttps://orcid.org/0000-0002-8526-6937BERNARDO LEMOShttps://orcid.org/0000-0001-6996-9483Abstract Amyotrophic lateral sclerosis (ALS) is a complex and serious neurodegenerative disorder that develops in consequence of the progressive loss of the upper and lower motor neurons. Cases of ALS are classified as sporadic (sALS), or familial (fALS). Over 90% of cases are sALS, while roughly 10% are related to inherited genetic mutations (fALS). Approximately 70% of the genetic mutations that contribute to fALS have been identified. On the other hand, the majority of the sALS cases have an undetermined genetic contributor and few mutations have been described, despite the advanced genetic analysis methods. Also, several factors contribute to the onset and progression of ALS. Numerous lines of evidence indicate that epigenetic changes are linked to aging, as well as neurodegenerative disorders, such as ALS. In most cases, they act as the heritable regulation of transcription by DNA methylation, histone modification and expression of noncoding RNAs. Mechanisms involving aberrant DNA methylation could be relevant to human ALS pathobiology and therapeutic targeting. Despite advances in research to find factors associated with ALS and more effective treatments, this disease remains complex and has low patient survival. Here, we provide a narrative review of the role of DNA methylation for this complex neurodegenerative disorder.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000500801&lng=en&tlng=enAmyotrophic lateral sclerosisDNA methylationneurodegenerative processneuroepigenetics |
| spellingShingle | ADRIANA HELENA DE OLIVEIRA REIS LUNA B. FIGALO MARCO ORSINI BERNARDO LEMOS The implications of DNA methylation for amyotrophic lateral sclerosis Anais da Academia Brasileira de Ciências Amyotrophic lateral sclerosis DNA methylation neurodegenerative process neuroepigenetics |
| title | The implications of DNA methylation for amyotrophic lateral sclerosis |
| title_full | The implications of DNA methylation for amyotrophic lateral sclerosis |
| title_fullStr | The implications of DNA methylation for amyotrophic lateral sclerosis |
| title_full_unstemmed | The implications of DNA methylation for amyotrophic lateral sclerosis |
| title_short | The implications of DNA methylation for amyotrophic lateral sclerosis |
| title_sort | implications of dna methylation for amyotrophic lateral sclerosis |
| topic | Amyotrophic lateral sclerosis DNA methylation neurodegenerative process neuroepigenetics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000500801&lng=en&tlng=en |
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