Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern India
Phyllodes tumors are uncommon fibroepithelial neoplasms of breast. Heterologous sarcomatous differentiation of malignant phyllodes tumor (MPT) is a rare phenomenon as shown in the literature. Herein we report a series of nine cases from a tertiary care centre in Eastern India. Patients demographic d...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=3;spage=371;epage=376;aulast=Nayak |
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| author | Mamita Nayak Susama Patra Pritinanda Mishra Nibedita Sahoo Prakash Kumar Sasmal Tushar Subhadarshan Mishra |
| author_facet | Mamita Nayak Susama Patra Pritinanda Mishra Nibedita Sahoo Prakash Kumar Sasmal Tushar Subhadarshan Mishra |
| author_sort | Mamita Nayak |
| collection | DOAJ |
| description | Phyllodes tumors are uncommon fibroepithelial neoplasms of breast. Heterologous sarcomatous differentiation of malignant phyllodes tumor (MPT) is a rare phenomenon as shown in the literature. Herein we report a series of nine cases from a tertiary care centre in Eastern India. Patients demographic data and clinical details were obtained from the medical records. Histopathology and immunohistochemical studies were analysed and diagnosed accordingly. Out of 38 cases of PT, 13 were found to be MPT, of which 9 cases showed heterologous differentiation in the form of angiosarcoma, fibrosarcoma, undifferentiated sarcoma, extensive squamous differentiation and with lipomatous metaplasia. Proper diagnosis and subtyping of the sarcomatous component is essential for deciding the correct treatment modality and prognostication of the disease. However there is no clear cut treatment protocol is available because of paucity of data. |
| first_indexed | 2024-12-23T19:53:36Z |
| format | Article |
| id | doaj.art-a8776755bd294c809b425d9fa6b4fbce |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-23T19:53:36Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-a8776755bd294c809b425d9fa6b4fbce2022-12-21T17:33:19ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292017-01-0160337137610.4103/IJPM.IJPM_426_16Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern IndiaMamita NayakSusama PatraPritinanda MishraNibedita SahooPrakash Kumar SasmalTushar Subhadarshan MishraPhyllodes tumors are uncommon fibroepithelial neoplasms of breast. Heterologous sarcomatous differentiation of malignant phyllodes tumor (MPT) is a rare phenomenon as shown in the literature. Herein we report a series of nine cases from a tertiary care centre in Eastern India. Patients demographic data and clinical details were obtained from the medical records. Histopathology and immunohistochemical studies were analysed and diagnosed accordingly. Out of 38 cases of PT, 13 were found to be MPT, of which 9 cases showed heterologous differentiation in the form of angiosarcoma, fibrosarcoma, undifferentiated sarcoma, extensive squamous differentiation and with lipomatous metaplasia. Proper diagnosis and subtyping of the sarcomatous component is essential for deciding the correct treatment modality and prognostication of the disease. However there is no clear cut treatment protocol is available because of paucity of data.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=3;spage=371;epage=376;aulast=NayakHeterologousmalignantphyllodestransformation |
| spellingShingle | Mamita Nayak Susama Patra Pritinanda Mishra Nibedita Sahoo Prakash Kumar Sasmal Tushar Subhadarshan Mishra Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern India Indian Journal of Pathology and Microbiology Heterologous malignant phyllodes transformation |
| title | Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern India |
| title_full | Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern India |
| title_fullStr | Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern India |
| title_full_unstemmed | Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern India |
| title_short | Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern India |
| title_sort | malignant phyllodes tumor with heterologous differentiation clinicopathological spectrum of nine cases in a tertiary care institute in eastern india |
| topic | Heterologous malignant phyllodes transformation |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=3;spage=371;epage=376;aulast=Nayak |
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