Controlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applications
Production of nanocomposite alginate microbeads with electrochemically synthesized silver nanoparticles (AgNPs) based on electrostatic extrusion technique was investigated with respect to potentials for utilization in pharmaceutical and biomedical applications. It was shown that electrochemical...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2012-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391200148S.pdf |
| _version_ | 1818756779827265536 |
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| author | Jovanović Željka Mišković-Stanković Vesna Obradović Bojana Stojkovska Jasmina Zvicer Jovana |
| author_facet | Jovanović Željka Mišković-Stanković Vesna Obradović Bojana Stojkovska Jasmina Zvicer Jovana |
| author_sort | Jovanović Željka |
| collection | DOAJ |
| description | Production of nanocomposite alginate microbeads with electrochemically synthesized silver nanoparticles (AgNPs) based on electrostatic extrusion technique was investigated with respect to potentials for utilization in pharmaceutical and biomedical applications. It was shown that electrochemical synthesis of AgNPs results in reduction of practically all Ag+ ions present in the initial solution yielding stable Ag/alginate colloid solutions that were demonstrated to be suitable for sterilization, manipulation, and electrostatic extrusion with retention of AgNPs. Presence of AgNPs in alginate colloid solutions had negligible effects on the size of the produced Ag/alginate microbeads, which was chiefly determined by the applied electrostatic potential during the extrusion. On the other hand, incorporation of AgNPs within the alginate hydrogel induced slight changes in biomechanical properties determined in a biomimetic bioreactor, so that packed beds of nanocomposite Ag/alginate microbeads exhibited slightly higher dynamic compression modulus as compared to that of control alginate microbeads (154 ± 4 and 141 ± 2 kPa, respectively). On the other hand, equilibrium unconfined compression modulus was significantly lower for nanocomposite microbeads as compared to that of controls (34 ± 2 and 47 ± 0.5 kPa, respectively). [Projekat Ministarstva nauke Republike Srbije, br. III 45019 i br. Eureka E!6749] |
| first_indexed | 2024-12-18T06:00:28Z |
| format | Article |
| id | doaj.art-a87a1b721979464ab6b4f49d4368be78 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-18T06:00:28Z |
| publishDate | 2012-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-a87a1b721979464ab6b4f49d4368be782022-12-21T21:18:42ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392012-01-0177121709172210.2298/JSC121108148SControlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applicationsJovanović ŽeljkaMišković-Stanković VesnaObradović BojanaStojkovska JasminaZvicer JovanaProduction of nanocomposite alginate microbeads with electrochemically synthesized silver nanoparticles (AgNPs) based on electrostatic extrusion technique was investigated with respect to potentials for utilization in pharmaceutical and biomedical applications. It was shown that electrochemical synthesis of AgNPs results in reduction of practically all Ag+ ions present in the initial solution yielding stable Ag/alginate colloid solutions that were demonstrated to be suitable for sterilization, manipulation, and electrostatic extrusion with retention of AgNPs. Presence of AgNPs in alginate colloid solutions had negligible effects on the size of the produced Ag/alginate microbeads, which was chiefly determined by the applied electrostatic potential during the extrusion. On the other hand, incorporation of AgNPs within the alginate hydrogel induced slight changes in biomechanical properties determined in a biomimetic bioreactor, so that packed beds of nanocomposite Ag/alginate microbeads exhibited slightly higher dynamic compression modulus as compared to that of control alginate microbeads (154 ± 4 and 141 ± 2 kPa, respectively). On the other hand, equilibrium unconfined compression modulus was significantly lower for nanocomposite microbeads as compared to that of controls (34 ± 2 and 47 ± 0.5 kPa, respectively). [Projekat Ministarstva nauke Republike Srbije, br. III 45019 i br. Eureka E!6749]http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391200148S.pdfelectrochemical synthesiselectrostatic extrusionsterilizationbiomechanical properties |
| spellingShingle | Jovanović Željka Mišković-Stanković Vesna Obradović Bojana Stojkovska Jasmina Zvicer Jovana Controlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applications Journal of the Serbian Chemical Society electrochemical synthesis electrostatic extrusion sterilization biomechanical properties |
| title | Controlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applications |
| title_full | Controlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applications |
| title_fullStr | Controlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applications |
| title_full_unstemmed | Controlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applications |
| title_short | Controlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applications |
| title_sort | controlled production of alginate nanocomposites with incorporated silver nanoparticles aimed for biomedical applications |
| topic | electrochemical synthesis electrostatic extrusion sterilization biomechanical properties |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391200148S.pdf |
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