The Impact of the Blood Lipids Levels on Arterial Stiffness
Arterial stiffness is a recognized predictor of cardiovascular morbidity and death. It is an early indicator of arteriosclerosis and is influenced by numerous risk factors and biological processes. The lipid metabolism is crucial and standard blood lipids, non-conventional lipid markers and lipid ra...
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Language: | English |
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MDPI AG
2023-03-01
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Series: | Journal of Cardiovascular Development and Disease |
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Online Access: | https://www.mdpi.com/2308-3425/10/3/127 |
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author | Mirela Baba Mihaela Maris Daniela Jianu Constantin Tudor Luca Dana Stoian Ioana Mozos |
author_facet | Mirela Baba Mihaela Maris Daniela Jianu Constantin Tudor Luca Dana Stoian Ioana Mozos |
author_sort | Mirela Baba |
collection | DOAJ |
description | Arterial stiffness is a recognized predictor of cardiovascular morbidity and death. It is an early indicator of arteriosclerosis and is influenced by numerous risk factors and biological processes. The lipid metabolism is crucial and standard blood lipids, non-conventional lipid markers and lipid ratios are associated with arterial stiffness. The objective of this review was to determine which lipid metabolism marker has a greater correlation with vascular aging and arterial stiffness. Triglycerides (TG) are the standard blood lipids that have the strongest associations with arterial stiffness, and are often linked to the early stages of cardiovascular diseases, particularly in patients with low LDL-C levels. Studies often show that lipid ratios perform better overall than any of the individual variables used alone. The relation between arterial stiffness and TG/HDL-C has the strongest evidence. It is the lipid profile of atherogenic dyslipidemia that is found in several chronic cardio-metabolic disorders, and is considered one of the main causes of lipid-dependent residual risk, regardless of LDL-C concentration. Recently, the use of alternative lipid parameters has also been increasing. Both non-HDL and ApoB are very well correlated with arterial stiffness. Remnant cholesterol is also a promising alternative lipid parameter. The findings of this review suggest that the main focus should be on blood lipids and arterial stiffness, especially in individuals with cardio-metabolic disorders and residual cardiovascular risk. |
first_indexed | 2024-03-11T06:23:18Z |
format | Article |
id | doaj.art-a87b97db0c2942fc8b851cae70764466 |
institution | Directory Open Access Journal |
issn | 2308-3425 |
language | English |
last_indexed | 2024-03-11T06:23:18Z |
publishDate | 2023-03-01 |
publisher | MDPI AG |
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series | Journal of Cardiovascular Development and Disease |
spelling | doaj.art-a87b97db0c2942fc8b851cae707644662023-11-17T11:47:47ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-03-0110312710.3390/jcdd10030127The Impact of the Blood Lipids Levels on Arterial StiffnessMirela Baba0Mihaela Maris1Daniela Jianu2Constantin Tudor Luca3Dana Stoian4Ioana Mozos5Center for Translational Research and Systems Medicine, “Victor Babeş” University of Medicine and Pharmacy, 300173 Timisoara, RomaniaCenter for Translational Research and Systems Medicine, “Victor Babeş” University of Medicine and Pharmacy, 300173 Timisoara, Romania1st Department of Internal Medicine, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timisoara, Romania2nd Department of Internal Medicine, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaCenter for Translational Research and Systems Medicine, “Victor Babeş” University of Medicine and Pharmacy, 300173 Timisoara, RomaniaArterial stiffness is a recognized predictor of cardiovascular morbidity and death. It is an early indicator of arteriosclerosis and is influenced by numerous risk factors and biological processes. The lipid metabolism is crucial and standard blood lipids, non-conventional lipid markers and lipid ratios are associated with arterial stiffness. The objective of this review was to determine which lipid metabolism marker has a greater correlation with vascular aging and arterial stiffness. Triglycerides (TG) are the standard blood lipids that have the strongest associations with arterial stiffness, and are often linked to the early stages of cardiovascular diseases, particularly in patients with low LDL-C levels. Studies often show that lipid ratios perform better overall than any of the individual variables used alone. The relation between arterial stiffness and TG/HDL-C has the strongest evidence. It is the lipid profile of atherogenic dyslipidemia that is found in several chronic cardio-metabolic disorders, and is considered one of the main causes of lipid-dependent residual risk, regardless of LDL-C concentration. Recently, the use of alternative lipid parameters has also been increasing. Both non-HDL and ApoB are very well correlated with arterial stiffness. Remnant cholesterol is also a promising alternative lipid parameter. The findings of this review suggest that the main focus should be on blood lipids and arterial stiffness, especially in individuals with cardio-metabolic disorders and residual cardiovascular risk.https://www.mdpi.com/2308-3425/10/3/127arterial stiffnessvascular agingblood lipidsatherogenic dyslipidemiaresidual cardio-vascular risk |
spellingShingle | Mirela Baba Mihaela Maris Daniela Jianu Constantin Tudor Luca Dana Stoian Ioana Mozos The Impact of the Blood Lipids Levels on Arterial Stiffness Journal of Cardiovascular Development and Disease arterial stiffness vascular aging blood lipids atherogenic dyslipidemia residual cardio-vascular risk |
title | The Impact of the Blood Lipids Levels on Arterial Stiffness |
title_full | The Impact of the Blood Lipids Levels on Arterial Stiffness |
title_fullStr | The Impact of the Blood Lipids Levels on Arterial Stiffness |
title_full_unstemmed | The Impact of the Blood Lipids Levels on Arterial Stiffness |
title_short | The Impact of the Blood Lipids Levels on Arterial Stiffness |
title_sort | impact of the blood lipids levels on arterial stiffness |
topic | arterial stiffness vascular aging blood lipids atherogenic dyslipidemia residual cardio-vascular risk |
url | https://www.mdpi.com/2308-3425/10/3/127 |
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